conclusions the study demonstrated that 1000 iu vitamin d supplementation for 3 months can decrease the insulin resistance in individuals with prediabetes; however, it has no significant effect on body fat mass percentage. background low serum levels of vitamin d are supposed to contribute to the incidence of diabetes; therefore, vitamin d supplementation may reduce the incidence of diabetes in...

Abstract Introduction: Ertugliflozin (ERTU), a sodium-glucose cotransporter 2 (SGLT2) inhibitor, is approved as an adjunct to diet and exercise improve glycemic control in patients with type diabetes mellitus (T2DM). Aim: As pre-specified sub-study of the Phase 3 VERTIS CV trial (NCT01986881), efficacy safety ERTU were assessed T2DM established atherosclerotic cardiovascular disease (ASCVD) ina...

In this 28-day, randomised, double-blind, placebo-controlled trial, 100 adults with self-reported poor sleep received either a placebo or standardised Bacopa monnieri extract (150 mg twice daily). Outcome measures included the Bergen Insomnia Scale (primary outcome measure), Functional Outcomes of Sleep Questionnaire, Pittsburgh Diary, Short Form-36 Health Survey, and Depression, Anxiety, Stres...

The use of tramadol is a controversial topic in cycling. In order to provide novel evidence on this issue, we tested 29 participants pre-loaded cycling time trial (TT; 20-min TT preceded by 40-min constant work-rate at 60% the VO2max) after ingesting 100 mg (vs placebo and paracetamol (1.5 g)). Participants performed Psychomotor Vigilance Task (PVT) rest Sustained Attention Response (SART) duri...

Abstract Background Patients with major depressive disorder (MDD) often do not respond to antidepressant (ADT) monotherapy alone and may require adjunctive treatment provide adequate symptom relief. Cariprazine (CAR) is a dopamine D 3 -preferring /D 2 serotonin 5-HT 1A receptor partial agonist approved treat adults schizophrenia manic, mixed, or episodes of bipolar I disorder. Post hoc analysis...