The objective of this experiment is to formulate the tigecycline injection by lyophillization technique for better stability and for long term storage. Lactose monohydrate and lactose sprat dried were used with water for injection and hydrochloric acid into 5 ml tubular vials with pre and post purging nitrogen. The filled vials were loaded into lyophilizer and lyophilized them as per cycle. Dif...

A new fast multipole formulation for the hypersingular BIE (HBIE) for 2D elasticity is presented in this paper based on a complex-variable representation of the kernels, similar to the formulation developed earlier for the conventional BIE (CBIE). A dual BIE formulation using a linear combination of the developed CBIE and HBIE is applied to analyze multi-domain problems with thin inclusions or ...

a gradient reversed-phase high performance liquid chromatography (hplc) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (gnrh) antagonistic activity used in infertility treatment. the hplc method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ich guidelines. the chromatograph...

abstract the objective of present study was to evaluate pharmacokinetic parameters of dibudipine phytosolve after oral administration in rats. the solubility test was carried out to select suitable oily solvent for dibudipine. phytosolve formulation was prepared with a medium chain triglyceride (mct) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). the effect of polyol c...

omega-3 fatty acids (fas) have been shown to prevent cardiovascular disease. the most commonly used omega-3 fatty acids like eicosapentaenoic acid (epa) and docosahexaenoic acid (dha) are highly vulnerable to oxidation and therefore, have short shelf life. recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 fas. several methods could be implemented to prepar...

The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and e...

Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 sec using super-disintegrants, special polymers, water soluble and even inso...

1 1 GENERAL INTRODUCTION 3 1.1 Endothelial related diseases 3 1.2 siRNA and the principle of RNA interference 8 1.3 RNA interference in research and therapy 13 1.4 Viral and non-viral gene delivery 14 1.5 Nanoparticles: definitions, history and current state of knowledge 16 1.6 Gelatin based nanoparticles as colloidal drug delivery vectors 18 1.7 Body distribution of nanoparticles 19 1.8 Nanopa...

The current commercial application of ink-jet reactive inks to cotton fabrics has been through pre-treating with pad liquor prior to printing. In This study made an effort to provide a single phase ink-jet printing process for printing cotton fabric using the novel cationic reactive dye in ink’s formulation. Cotton fabric was printed upon with the novel cationic reactive dye and commercial anio...