Analysis of histopathological sections by image analysis software and Immunohistochemical localization for investigation of different protein expression patterns can be used as a valued tool for detection of progress of malignancy in oral cancer. The present study has applied microscopic analysis for different sections of oral precancerous conditions and lesions such as Oral Submucous Fibrosis,...

BACKGROUND The present study was undertaken to estimate and compare the levels of plasma total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and triglycerides in patients with oral precancerous lesions/conditions, oral cancer and normal subjects. MATERIALS AND METHODS The study comprised of 60 patients with oral precancero...

Detailed mechanistic modelling has been performed of the intercellular signalling cascade between precancerous cells and their normal neighbours that leads to a selective removal of the precancerous cells by apoptosis. Two interconnected signalling pathways that were identified experimentally have been modelled, explicitly accounting for temporal and spatial effects. The model predicts highly n...

Precancerous skin lesions are associated with high probability of malignant transformation to squamous cell carcinoma. Early detection and management necessary improve prognosis outcomes. Literatures showed that topical photodynamic therapy (PDT) is a promising treatment method which can be successfully applied in several conditions dermatology. This study aims review the efficacy PDT for vario...

The purpose of this experimental work was to determine whether the precancerous loss of rat liver 5-hydroxytryptophan (5-HT) decarboxylase was associated with sequential atrophic alterations preceding hepatocarcinogenesis. To test whether such an association existed, three experimental conditions were employed in which hepato carcinogenesis was either markedly delayed or prevented. Under all th...