The hepatic microsomal enzyme UDP-glucuronyltransferase undergoes a complex developmental pattern in which enzyme activity is first detectable on the 18th day of gestation in rats. Prepubertal activities are similar for males and females. However, postpubertal sexual differentiation of enzyme activity occurs in which male activities are twice those of females. Neonatal administration of testost...

Data from both in vivo and in vitro experiments demonstrated that glabridin and glabrene are similar to estradiol-17beta in their stimulation of the specific activity of creatine kinase, although at higher concentrations, but differ in their extent of action and interaction with other drugs. In pre-menopausal human bone cells, the response to estradiol-17beta and glabridin (at higher concentrat...

Bisphenol A (BPA) is widely used in manufacturing industries. It is commonly detected in the environment and was reported to exert oestrogenic effects which may be harmful to the reproductive system. The present study was carried out to observe the effects of oral administration of BPA on the development of the reproductive organs and plasma sex hormone levels in prepubertal male Sprague-Dawley...

Ghrelin, a gut peptide with key actions on food intake and GH secretion, has been recently recognized as potential regulator of reproductive function. Thus, in adult female rats, ghrelin has been proven to modulate GnRH/LH secretion, with predominant inhibitory effects in vivo. We analyze herein potential direct pituitary effects of ghrelin on basal and GnRH-stimulated gonadotropin secretion in...

The observations that substance P (SP) is localized in the anterior pituitary gland (AP) and is regulated by the hormonal status of the animal, as well as the demonstration of SP binding sites in the AP, have led to the idea that SP may participate in the regulation of AP function. Numerous and sometimes contradictory reports of SP effects on AP hormone secretion, particularly on luteinizing ho...

BACKGROUND Previous researches about the effects of epididymal obstruction on the testes are contradictory, and the mechanism harmful effect of male duct system obstruction on seminiferous tubules still remains unclear. OBJECTIVE The aim of this study was to investigate the effects of epididymal obstruction in prepubertal rats on the testis. MATERIALS AND METHODS 15 days of age, the young r...

Reproductive toxicity during prepubertal and pubertal period causes significant alterations in sexual maturation fertility. Bisphenol A has been associated with decreased sperm production, damaged testicular cells, perturbed hormone levels reduced Its role maturity duration before first successful mating is still elusive. The present study aimed to investigate BPA induced alteration development...

Prepubertal removal of the pituitary gland, which in young animals influences sexual maturation, reduces significantly the amount of retinal photoreceptor destruction when the rats are exposed to continuous illumination in adulthood. When crude pituitary gland homogenate is administered to adult rats hypophysectomized prior to puberty, photoreceptor destruction is more severe. Transplantation o...

Introduction Effects of hyponatraemia on the paediatric central nervous system In the United States, there are an estimated 15 000 deaths per year as a consequence of postoperative Nattie & Edwards (15) studied the effects of acute hyponatraemia (1) (Figure 1). There have been a hyponatraemia on the brain of puppies. They found number of recent studies which have described that acute lowering o...

PURPOSE The aim of this work was to analyze the bladder wall modifications after a chronic treatment with high doses of corticosterone in prepubertal rats. METHODS This study included 26 male rats assigned into four groups: T30 was treated with corticosterone until 29 days of age and killed at day 30, while T65 group received the same treatment but was killed at day 65. Each group had its own...