The Effects of pH Gradients on the Action of Procaine and Lidocaine in Intact and Desheathed Sciatic Nerves. GEORGE E. STROBEL AND C. PAUL BIANC1II 1 The Effects of pH Gradients on the Uptake and Distribution of C14-Procaine and Lidocaine in Intact and Desheathed Sciatic Nerve Trunks. GEORGE E. STROBEL AND C. PAULBIANCHI 18 Sites of Action of SKF 525-A in Nerve and Muscle. G. SUAREZ-KURTZ AND C...

In a study of 121 men with uncomplicated gonococcal urethritis, 64 were treated orally with a single dose of 3 g amoxycillin and 250 mg of the specific beta-lactamase inhibitor, clavulanic acid, and 57 with a single intramuscular injection of 2.4 MU procaine penicillin. After seven days, six (9.4%) patients treated with amoxycillin and clavulanic acid were still culture positive for Neisseria g...

The extra-cardiac sites of action of strophanthin-K, quinidine and procaine amide have been investigated by injection of varying doses into the third ventricle of unanesthetized dogs. A profuse autonomic nervous system discharge was produced. Strophanthin-K produced a paroxysmal ventricular tachycardia resulting in death by ventricular fibrillation. Such effects could be blocked by prior intrav...

The phase behaviour and surface structure of dipalmitoyl phosphatidyl choline (DPPC) monolayers at the air/water interface, in the absence and the presence of procaine, have been investigated by LangmuirBlodgett (LB) technique and atomic force microscopy. The LB films were transferred on mica, at a controlled surface pressure, characteristic for the expanded liquid to condensed liquid phase tra...

The authors reply: To the Editor: As stated by Dr. Bete, studies of Purkinje fiber bundles perfused with physiologic salt solution have shown that procaine amide prolongs the action potential duration (APD) and the effective refractory period (ERP), the latter to a greater extent than the former.' We did not discuss the differences Dr. Bete has noted in calculating the AAPD/AERP ratio for our s...

In order to determine whether or not atropine, procaine, and tetrodotoxin (TTX) can stimulate intestinal smooth muscle directly, we examined the effects of these drugs on the mechanical and electrical activities of several types of cat intestinal smooth muscle preparations. The preparations consisted of isolated rings of 1) intact intestinal wall, 2) intact longitudinal and circular muscle, 3) ...

Mouse fibroblast LM cells have been modified with respect to the content of polyunsaturated fatty acyl (PUFA) chains of the membrane phospholipids. The membranes of the modified cells were enriched in PUFA chains and were more fluid as compared to the normal cells, as judged by fluorescence polarization measurements. The thermosensitivity of the PUFA-substituted cells was enhanced. Thermotolera...