Protein-protein interaction network represents an important aspect of systems biology. The understanding of the plant protein-protein interaction network and interactome will provide crucial insights into the regulation of plant developmental, physiological, and pathological processes. In this review, we will first define the concept of plant interactome and the protein-protein interaction netw...

Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel p...

Protein-protein interactions play a major role in most cellular processes. Thus, the challenge of identifying the full repertoire of interacting proteins in the cell is of great importance, and has been addressed both experimentally and computationally. Today, large scale experimental studies of interacting proteins, while partial and noisy, allow us to characterize properties of interacting pr...

AIM The aim of this study is to investigate the Protein-Protein Interaction Network of Celiac Disease. BACKGROUND Celiac disease (CD) is an autoimmune disease with susceptibility of individuals to gluten of wheat, rye and barley. Understanding the molecular mechanisms and involved pathway may lead to the development of drug target discovery. The protein interaction network is one of the suppo...

Aim Gene assessment of pancreatic adenocarcinoma disease via protein-protein interaction (PPI) Network Analysis. Background Diagnosis, especially early detection of pancreatic adenocarcinoma as a lethal disease implies more investigation. PPI Network Analysis is a suitable tool to discover new aspects of molecular mechanism of diseases. Methods In the present study the related genes to panc...

Proteins are linear polymers built from 20 building blocks called amino acids. Parts of a protein that are found conserved in many other proteins are called domains; these domains are usually responsible for the protein-protein interactions. Protein-protein interactions (PPIs) are transient or permanent connections between proteins, and they are important for many biological phenomena such as s...