Cholestatic pruritus is one of the most common complaints in patients with liver diseases and intraor posthepatic cholestasis. The mechanisms of cholestatic pruritus remain poorly understood although multiple factors are considered to participate in the pathogenesis of cholestatic pruritus. Recent exciting studies have discovered several G-protein coupled receptors (GPCRs) and endogenous chemic...

Pruritus occurs frequently in the elderly population, but it has not been fully defined and its precise prevalence is unknown. Putative causes of pruritus are numerous and patients' quality of life can be greatly reduced. In the absence of any specific cause, a diagnosis of senile pruritus is proposed, suggesting that itch is secondary to ageing. However, the relationship of pruritus with skin ...

Zusammenfassung Chronischer Pruritus ist ein häufiges Symptom mit einer Prävalenz von rund 15 %. Neben klassischen Hauterkrankungen wie der atopischen Dermatitis oder Psoriasis leiden auch zahlreiche Patienten internistischen, neurologischen und psychiatrischen Krankheitsbildern an Pruritus. Die häufigsten internistischen Ursachen des chronischen sind chronische Niereninsuffizienz, Leber- Galle...

OBJECTIVE Antagonism of the central nervous system inhibitor neurotransmitter gamma-Aminobutyric acid (GABA) or serotonergic system activation is an important factor in the pathogenesis of intrathecal morphine-induced pruritus. This study tested the hypothesis that preoperative use of ondansetron, gabapentin or mirtazapine can prevent morphine-induced pruritus. METHODS We randomly allocated 8...