Total left ventricular external power and aortic input impedance spectra were calculated from recordings of pulsatile pressure and flow in the ascending aorta of 22 human subjects undergoing cardiac catheterization. Eleven subjects had increased aortic pressure (systolic 153 + 3.8[SEM] mm Hg, p < .001; diastolic 91 + 2.4 mm Hg, p < .03; mean 118 ± 2.4 mm Hg, p < .001) and constituted the group ...

Trabeculectomy, despite producing an effective reduction in intraocular pressure, may not prevent continued visual field loss. This may be because of the presence of other factors in the pathogenesis of glaucoma. Vascular factors have been suggested as being particularly important. To study the effect of trabeculectomy on ocular blood flow the technique of ocular pulse analysis has been used to...

The analysis of solute and thermal dispersion in pulsatile flow through the stenotic tapered blood vessel is presented. The present problem is an extension of the work done by Ramana et al. who considered the time-invariant arterial wall. In the present model, the flexible nature of the arterial wall through the obstruction (called stenosis) is considered and it is achieved with the he...

We present an immersed boundary method based on volume penalization, with which pulsatile flow in a model cerebral aneurysm is simulated. The model aneurysm consists of a curved vessel merged with a spherical cavity. The dominant vortical structures arising in the time-dependent flow are discussed and the evolution of the maximal shear stress in the aneurysm is analyzed. We approximate flow pro...

Drug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors associated with the pulsatile nature of blood flow and their impact on arterial drug deposition have not been fully investigated. We employed an integrated framework compris...

Huo, Yunlong, and Ghassan S. Kassab. Pulsatile blood flow in the entire coronary arterial tree: theory and experiment. Am J Physiol Heart Circ Physiol 291: H1074–H1087, 2006. First published April 14, 2006; doi:10.1152/ajpheart.00200.2006.—The pulsatility of coronary circulation can be accurately simulated on the basis of the measured branching pattern, vascular geometry, and material propertie...

In this day and age of cardiovascular surgery with cardiopulmonary bypass (CPB), the perfusionist strives to maintain or mimic normal physiologic parameters such as blood gases, electrolytes, blood flows and so on. The surgical team employes such myocardial protection techniques as topical cooling and cardioplegia. The anaesthesiologist endeavours to maintain hemodynamic and respiratory paramet...