Low-dose ionizing radiation alters the gene expression profiles of mammalian cells, yet there is little understanding of the underlying cellular mechanisms responsible for these changes or of their consequences for genomic stability. We investigated the cytogenetic adaptive response of human lymphoblastoid cell lines exposed to 5 cGy (priming dose) followed by 2 Gy (challenge dose) compared to ...

today, nuclear medicine has rapidly been developed so that in some cases, plays a unique role in diagnosis but unfortunalty in spite of diagnostic and therapeutic advantages, the term “nuclear” can induce worries in patients and society. in this article, base on new documents, we intend to show that this worries has no scientific basis. to produce a realistic view, regarding to radiation protec...

The question of whether very small doses of ionizing radiation really exert stochastic effects (i.e. induce harmful genetic effects, including cancer in a probablistic manner) has not been unequivocally settled. The much relied upon linear, no-threshold (LNT) hypothesis does not have convincing experimental evidence. As there are practical difficulties in generating data on genetic effects at v...

In this study, microbeam protons were used to provide the priming dose to induce an in vivo radioadaptive response (RAR) in the embryos of zebrafish, Danio rerio, against subsequent challenging doses provided by x-ray photons. The microbeam irradiation system (Single-Particle Irradiation System to Cell, acronym SPICE) at the National Institute of Radiological Sciences (NIRS), Japan, was employe...

  Today, nuclear medicine has rapidly been developed so that in some cases, plays a unique role in diagnosis but unfortunalty in spite of diagnostic and therapeutic advantages, the term “NUCLEAR” can induce worries in patients and society. In this article, base on new documents, we intend to show that this worries has no scientific basis. To produce a realistic view, ...

Background: Hormesis is defined as the bio-positive response of something which is bio-negative in high doses. In the present study, the effect of radiation hormesis was evaluated on the survival rate of immunosuppressed BALB/c mice by Cyclosporine A.Materials and Methods: We used 75 consanguine, male, BALB/c mice in this experiment. The first group received Technetium-99m (3700Bq) and the seco...

There is a relationship between various cellular stress factors and aging. In earlier studies, we demonstrated that overexpression of the D-GADD45 gene increases the life span of Drosophila melanogaster. In this study, we investigate the relationship between D-GADD45 activity and resistance to oxidative, genotoxic and thermal stresses as well as starvation. In most cases, flies with constitutiv...