نتایج جستجو برای: reactive hyperplasia
تعداد نتایج: 189080 فیلتر نتایج به سال:
Genetic deficiency in CD18 leads to disease characterized by myeloid hyperplasia, including profound granulocytosis and splenomegaly. Myeloid hyperplasia could directly result from the disruption of CD18 functions essential to granulopoiesis or basal leukocyte trafficking. Alternatively, myeloid hyperplasia could be reactive in nature, due to disruption of essential roles of CD18 in leukocyte r...
Abstract Pure erythroid leukemia (PEL) is a rare, aggressive subtype of acute myeloid with poor prognosis. The diagnosis PEL often medically urgent, quite challenging, and typically exclusion requiring meticulous distinction from non-neoplastic proliferations, particularly florid hyperplasia/regeneration. Given the frequency TP53 mutations in molecular signature PEL, we hypothesize that differe...
Introduction: Most B-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. Some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. Molecular techniques can be used as a helpful diagnostic tool in these cases. In this study, we assessed the value of polymerase chain reaction (PCR) t...
The diagnosis of follicular dendritic cell (FDC) sarcoma can be challenging because of its morphologic overlaps with many other spindle cell neoplasms and, therefore, new phenotypic markers will be helpful in its differential diagnosis. Podoplanin is a mucin-type transmembrane glycoprotein that has recently been detected in reactive FDCs. In this study, we investigated the expression patterns o...
We describe 6 cases from the University of Washington Hematopathology Laboratory (Seattle) in which prominent, clonal, follicle center B-cell populations were identified by flow cytometry and confirmed by molecular methods, but in which the histologic features showed reactive follicular hyperplasia without evidence of bcl-2 overexpression or the t(14;18). The 6 cases included 5 lymph node biops...
OBJECTIVES To present and discuss 2 patients with acquired peripapillary pigmented lesions. METHODS We reviewed the patients' clinical records and histopathologic findings. RESULTS The first patient was diagnosed with a pigmented papillary lesion that was followed up for 38 years. The second patient was a child with neurofibromatosis type 1 who developed a pigmented peripapillary lesion fol...
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