the present study was designed to investigate the protective effect of ethanol extracts from lindera coreana leaves (lce) on uvb-induced oxidative stress in hacat keratinocytes. the hacat cells were pretreated with lce for 24 h and then exposed to uvb (20 mj/cm2) for 2 h. uvb significantly decreased the cell viability (p<0.05). lce did not exhibit significantly cytotoxic effects and increased t...

programmed cell death is a highly regulated form of cell death, mostly distinguished by the activation of a family of cystein-aspartate proteases (caspases) that cleave various proteins resulting in morphological and biochemical changes characteristic of this form of cell death. several recent studies have addressed the role of programmed cell death in inflammatory and chronic pain states. casp...

bronchial asthma is the common chronic inflammatory disease and is characterized by chronic airway inflammation, airway remodeling, and airway hyperreactivity (ahr). aim of this study was to investigate the effects of mitochondrial atp-sensitive potassium channels (mitokatp) on the proliferation and secretion of human airway smooth muscle cells (hasmcs). hasmcs were treated with the serum from ...

the use of low level laser to reduce pain, inflammation and edema, to promote wound, deeper tissues and nerves healing, and to prevent tissue damage has been known for almost forty years since the invention of lasers. this review will cover some of the proposed cellular mechanisms responsible for the effect of visible light on mammalian cells, including cytochrome c oxidase (with absorption pea...

A colorimetric and fluorescent probe C-Py-1 for ONOO(-) was prepared and it could exhibit high sensitivity and excellent selectivity toward ONOO(-) among reactive oxygen species (ROS) and reactive nitrogen species (RNS) with a rapid response time in 100% water solution. Meanwhile, C-Py-1 was successfully applied in the imaging of endogenous ONOO(-) in RAW264.7 cells.

Reactive oxygen species (ROS) play key roles in many pathogenic processes, including carcinogenesis, inflammation, ischemia-reperfusion injury and signal transduction. Also, reactive nitrogen species (RNS) cause various biological events such as neurodegenerative disorders. Sensitive and specific detection methods for ROS and RNS in biological samples should be useful for elucidation of biologi...

objective(s):  the role of the apoptosis repressor with caspase recruitment domain (arc) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of endothelin-1 induced cardiac hypertrophy remains unknown. the present study discusses the inhibitory role of arc against endothelin–induced hypertrophy. results:in present study endothelin treated card...

D ioxygen is a highly important, yet toxic, molecule that reacts in vivo to produce reactive oxygen species such as superoxide, peroxides, hydroxyl radicals, and other related species. Those species play important roles in healthy organisms, and they are implicated in aging and a wide range of disease processes as well. The contents of this Special Feature on Reactive Oxygen Species in Chemistr...