Visual cell pathologic changes and outer segment renewal were investigated in miniature poodles with progressive rod-cone degeneration. Early in this disease, visual cells in the posterior pole and equatorial regions show outer segment lamellar disorientation and vesicular profiles. Visual cells are normal in the periphery. Outer segment renewal determined after intravitreal injection of 3H-leu...

In this study, we characterized the self-renewal capability, multi-lineage differentiation capacity, and clonogenic efficiency of human dental pulp stem cells (DPSCs). DPSCs were capable of forming ectopic dentin and associated pulp tissue in vivo. Stromal-like cells were reestablished in culture from primary DPSC transplants and re-transplanted into immunocompromised mice to generate a dentin-...

Urban regeneration and renewal is one of the urban development subjects that have undergone substantial changes in last decades in its approaches and also management process. Despite these global changes, policy making in this field of urban development have been delayed in Iran. In the last three decades, the spread of distressed urban areas in Tehran and their vulnerability against earthquake...

AIMS This retrospective analysis sought to develop and validate a model using the measured diagnostic variables in cardiac resynchronization therapy (CRT) devices to predict mortality. METHODS AND RESULTS Data used in this analysis came from two CRT studies: Cardiac Resynchronization Therapy Registry Evaluating Patient Response with RENEWAL Family Devices (CRT RENEWAL) (n = 436) and Heart Fai...

AML1-ETO (AE) is a fusion product of translocation (8;21) that accounts for 40% of M2 type acute myeloid leukemia (AML). In addition to its role in promoting preleukemic hematopoietic cell self-renewal, AE represses DNA repair genes, which leads to DNA damage and increased mutation frequency. Although this latter function may promote leukemogenesis, concurrent p53 activation also leads to an in...

Background: Any irregularities in self-renewal/differentiation balance in endometriotic MSCs can change their fate and function, resulting in endometriosis development. This study aimed to evaluate the expression of OCT4 transcripts (OCT4A, OCT4B, and OCT4B1), SOX2, and NANOG in endometriotic MSCs to show their aberrant expression and to support self-renewal/differentiation imbalance in these c...

A nonstationary point process can be efficiently simulated by exploiting a representation as the composition of a rate-one process and the cumulative arrival rate function, provided that an efficient algorithm is available for generating the rate-one process, as is the case for stationary renewal processes, Markov modulated Poisson processes and many other processes. Overall efficiency can be a...

This paper introduces a simple index that helps to assess the degree of aging or rejuvenation of repairable systems. The index ranges from -1 to 1. It is negative for the point processes with decreasing ROCOF and is positive for the point processes with increasing ROCOF. Index Terms aging, rejuvenation, homogeneity, non-homogeneity. ACRONYMS CDF cumulative distribution function CIF cumulative i...