BACKGROUND Phaxan™ (PHAX, Chemic Labs, Canton, MA) is an aqueous solution of 10 mg/mL alphaxalone and 13% 7-sulfobutylether β-cyclodextrin (betadex). In preclinical studies, PHAX is a fast onset-offset IV anesthetic like propofol, but causes less cardiovascular depression. This first-in-man study was designed to find the anesthetic dose of PHAX and to compare it with an equivalent dose of propo...

Introduction: Preoperative anxiety is an issue of concern in paediatric anaesthesia practice. Forceful transfer children into the operating room can cause long-term psychological trauma. This clinical study compares intramuscular ketamine and a combination dexmedetomidine as anaesthetic premedicants terms +anxiolysis, sedation ease IV cannulation.
 Objectives: To compare level preoperative...

CONTEXT Observer-based sedation scales have been used to provide a measurable estimate of the comfort of nonalert patients in palliative sedation. However, their usefulness and appropriateness in this setting has not been demonstrated. OBJECTIVES To study the reliability and validity of observer-based sedation scales in palliative sedation. METHODS A prospective evaluation of 54 patients un...

Background Agitation is a frequent complication in critically ill adults, can result in life-threatening events for patients or care providers, and extends the hospital length of stay, thereby increasing hospital costs. Objectives To describe the incidence, onset, and temporal factors related to agitation in critically ill adults. Methods Data were collected for the first 5 days of stay of all ...

BACKGROUND We evaluated the use of dexmedetomidine to facilitate the weaning of delirious postoperative patients from mechanical ventilation. METHODS We included 72 consecutive patients who underwent elective cardiac surgery in this prospective observational study. Each patient had failed at least 1 trial of continuous positive airway pressure (CPAP) and had agitation. Patients were assessed ...

BACKGROUND Endotracheal suctioning is a necessary procedure practiced by nurses in intensive care units to remove lung secretions. This procedure leads to higher oxygenation levels and reduced breathing difficulties. It also prevents atelectasis, pulmonary infections, and the accumulation of secretions. OBJECTIVES The present study aims to compare the effectiveness of open and closed endotrac...

This work focused on investigating therapeutic efficacy of sacral plexus block combined with dexmedetomidine in preventing catheter-related bladder discomfort patients receiving transurethral resection the prostate. Sixty undergoing elective prostatectomy were randomized as group D or M (n=30 each). Both groups given 0.5 μg/kg 10 min before induction general anesthesia. The severity score disco...

OBJECTIVES To describe the number and type of stimulation events and the relationship of stimulation to sedation level in patients receiving mechanical ventilation. METHODS A 4-hour direct observation was conducted in 103 patients receiving mechanical ventilation. Stimulation events and sedation level before and after the stimulation were documented. Eight categories of stimulation events wer...