AIMS Hybrid tumours of the salivary gland are rare neoplasms that have been described only in the parotid and palate. Their recognition is important particularly when the component tumours have different biological behaviours. The occurrence of a submandibular hybrid tumour has not been reported. METHODS AND RESULTS We describe a case of a 36-year-old woman with a hybrid carcinoma composed of...

alivary gland carcinosarcoma is an exceedingly rare and ggressive neoplasm composed of a mixture of carcinomaous and sarcomatous components, with either component apable of metastasis. Salivary gland carcinosarcoma can rise in pleomorphic adenoma (PA) or de novo.1 The present study reports a case of the parotid gland de ovo carcinosarcoma, which contained salivary duct adenoarcinoma and sarcoma...

Salivary duct carcinoma (SDC) is an uncommon, aggressive tumour, which carries a poor prognosis. SDC affects the major salivary glands, usually occurring in the parotid gland. A 76-year-old male patient presented with right-sided nasal obstruction and rhinorrhoea. A polypoidal mass was seen in the right inferior turbinate mimicking a benign neoplasm. Histological examination following wide exci...

Background: Persistent thyroglossal duct leads to a fibrous cyst formation named thyroglossal cyst which is the most common form of congenital cyst and usually located in the midline neck below the hyoid bone. Rarely the thyroglossal cyst is associated with thyroid cancer. Although the Sistrunk procedure is often considered adequate, currently there is no clear consensus on the optimal manageme...

Salivary duct carcinoma (SDC) is a prototypic aggressive salivary gland carcinoma. Our aim is to determine the prevalence of histologic variants (micropapillary, basal-like) and androgen receptor (AR) expression in a large multi-institutional series of SDC. AR status was determined by immunohistochemistry (IHC). Most SDCs were characterized by an apocrine phenotype and AR expression. Cases with...

The authors report a case of a salivary duct carcinoma (SDC) of the parotid gland revealed by a facial palsy. The clinical and pathological features of this highly malignant neoplasm are described. The aggressive nature of this form demands a combined chemo-radio-surgical treatment; only early recognition and treatment are likely to result in a favourable outcome.

A 67-year-old male with three synchronous tumors in the unilateral parotid gland is reported. Postoperative histological examinations confirmed the presence of three synchronous primary tumors, specifically pleomorphic adenoma, Warthin's tumor and salivary duct carcinoma, in the right parotid gland. To our knowledge, this is the first case report describing three different histological types in...

introduction: malignant salivary gland tumors are rare entities. despite advances in surgery, radiation therapy and chemotherapy, the rate of the mortality and five-year survival has not been improved markedly over the last few decades. the activation of egfr- ras-raf signaling pathway contributes to the initiation and progression of many human cancers, promising a key pathway for therapeutic m...

Salivary duct carcinoma in the submandibular gland with HER-2 protein overexpression : A report of two cases : Nao Hiwatashi1,2), Shinji Takebayashi1), Chiaki Suzuki1), Takushi Miyoshi1), Hiroki Ikeda1) and Makoto Miura1). 1)Department of Otolaryngology, Japanese Red Cross Society Wakayama Medical Center, 2)Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto ...