BACKGROUND There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL-8, angiogenic factor, and vitamin D is still at the dawn of research. Henc...

UNLABELLED Background and Need for Novel Biomarkers: Brain tumors are the leading cause of death by solid tumors in children. Although improvements have been made in their radiological detection and treatment, our capacity to promptly diagnose pediatric brain tumors in their early stages remains limited. This contrasts several other cancers where serum biomarkers such as cancer antigen (CA) 19-...

Objective Clinically useful serum biomarkers for the diagnosis and monitoring of eosinophilic gastrointestinal diseases are not available. This study was conducted to examine the possible value of eosinophil-related proteins as serum biomarkers. Methods The serum concentrations of 49 cytokines, chemokines, and other proteins were measured in 29 patients with eosinophilic gastrointestinal diseas...

Background Cardiac biomarkers have become increasingly important in cardiovascular disease. With the ability to detect focal and diffuse myocardial fibrosis, CMR is an important imaging biomarker. Diffuse myocardial fibrosis, reflected by increased extracellular volume (ECV), may underlie increased cardiovascular risk. ECV could provide a novel tool to evaluate the association myocardial-specif...

background: recent epidemiological studies demonstrate that obesity is associated with an increased risk for breast cancer in women. increased estrogen levels are suggested as one possible explanation, but this does not fully explain the relationship between obesity and breast cancer. one alternative explanation is secretion by adipocytes of metabolites, hormones and cytokines, collectively kno...

Background: According to the recent studies, vitamin D deficiency has been correlated with progress in type 2 Diabetes and Metabolic Syndrome. The aim of this study was to assess the effect of vitamin D supplementation on glucose and lipid profiles, blood pressure, and biomarkers of liver and kidney in type 2 diabetic patients.    Methods: In this Double blinded randomized clinical t...

context primary liver cancer is one of the most common and deadly malignant neoplasms worldwide. the incidence and mortality rates for hepatocellular carcinoma (hcc) are virtually identical, reflecting the poor overall survival of patients with this kind of tumor. effective therapies mostly achieved if the hcc diagnosis is made at early stages of the tumor. surveillance tests include serologic ...

asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. to solve this paradox, we need objective airway biomarkers to tailor the proper medica...

Affinity-based electrochemical (EC) sensors offer a potentially valuable approach for point-of-care (POC) diagnostics applications, and the detection of diseases, such as sepsis, that require simultaneous multiple biomarkers, but their development has been hampered due to biological fouling EC noise. Here, an sensor platform enables sepsis biomarkers simultaneously by incorporating nanocomposit...

Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to diagnose, monitor, predict, and prognosticate disease. Biomarkers such as cardiac troponin and natriuretic peptides have some predictive value, but still lack reliability in this patient p...