Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell prolife...

Patterning of the Drosophila ventral epidermis is a tractable model for understanding the role of signalling pathways in development. Interplay between Wingless and EGFR signalling determines the segmentally repeated pattern of alternating denticle belts and smooth cuticle: spitz group genes, which encode factors that stimulate EGFR signalling, induce the denticle fate, while Wingless signallin...

Multicellular tissues are the building blocks of many biological systems and organs. These not static, but dynamically change over time. Even if overall structure remains same there is a turnover cells within tissue. This dynamic homeostasis maintaned by numerous governing mechanisms which finely tuned in such way that tissue homeostatic state, even across large timescales. Some these include c...

Low-grade gliomas (LGGs) are grade III based on the WHO classification with significant genetic heterogeneity and clinical properties. Traditional histological of has been challenged by improvement molecular stratification; however, reproducibility diagnostic accuracy LGGs still remain poor. Herein, we identified fatty acid binding protein 5 (FABP5) as one most enriched genes in malignant eleva...

During the past 50 years, growth and differentiation molecules have been identified and shown to contribute importantly to many different biological functions. One of these, the recently discovered neuregulin (NRG) and the associated erbB receptors were first found to be important for differentiation of the peripheral nervous system, where they direct the differentiation of Schwann cells from n...

We propose and estimate a novel transport layer mobility management scheme: Seamless IP diversity based Generalized Mobility Architecture (SIGMA). SIGMA provides seamless handover for mobile hosts and is based on Stream Control Transmission Protocol (SCTP), which is a new dependable transport protocol to transport SS7 signaling messages over IP network. We also show that our handover scheme can...