نتایج جستجو برای: solid dispersion technique

تعداد نتایج: 843136  

2007
Ali Nokhodchi Roya Talari Hadi Valizadeh Mohammad Barzegar Jalali

The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. The...

اکبری, جعفر, خانعلی پور, نگار, سعیدی, مجید, مرتضی سمنانی, کتایون,

Background and purpose: Piroxicam is a non-steroidal anti- inflammatory drug that is characterized by low solubility and high permeability. According to the biopharmaceutic drug classification system, piroxicam is a class 2 drug with low solubility and high permeability. The solid dispersion, ammroach is commonly used to improve the dissolution of poorly water soluble drugs using hydrophilic po...

2010
A. Sharma C.P. Jain

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carve...

2011
Ramadevi Bhimavarapu Karuna Priya Chitra

Solubility is an important physicochemical factor affecting absorption of drug and there by its therapeutic effect. About 40% of newly discovered drugs are lipophilic and failed to reach market due to their poor water solubility. Solid dispersions proved to have tremendous potential for improving drug solubility. Orlistat is a poor water soluble substance possessing anti-obesity property; in th...

2011
Abhisekh Das Amit Kumar Nayak Biswaranjan Mohanty Satyabrata Panda

The aim of the present study was to improve solubility and dissolution of the poorly aqueous soluble drug, etoricoxib by solvent evaporation technique using various sugar carriers, such as lactose, sucrose, and mannitol. Etoricoxib solid dispersions and their respective physical mixtures using lactose, sucrose, and mannitol were prepared in different ratios by solvent evaporation technique. The...

Dina Nath Mishra, Sengodan Gurusamy Vijaya Kumar,

Meloxicam is a non steroidal anti-inflammatory drug, used in the treatment of rheumatoid arthritis and oestoarthritis. It is practically insoluble in water leading to poor dissolution, variations in bioavailability and gastric irritation on oral administration. In order to modulate its gastric side effect and to increase aqueous solubility, physical mixture and solid dispersion of the drug were...

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