Somatotropin (ST) markedly decreases lipogenesis, fatty acid synthase (FAS) enzyme activity and mRNA abundance in pig adipocytes. The present study was conducted to determine whether the decrease in FAS mRNA in 3T3-F442A adipocytes was the result of a decrease in transcription of the FAS gene and/or a change in FAS mRNA stability. Insulin increased the abundance of FAS mRNA 2-13-fold and fatty ...

Somatotropin (STH) administered to earth gravity birds (1 g) stimulated the mean growth in height of the articular cartilage layer of the distal tibial epiphyses (DTE) and of the resting and proliferating layers of the proximal epiphyses of os tarsometatarsus (PE-TMT). However, it inhibited growth in height of the calcified cartilage zone of both epiphyses. Hypergravity control animals (2 g) sh...

The adaptation of human somatotropin and insulin assays to the automated Centria radioimmunoassay system [Clin. Chem. 21, 1305 (1975)] is reported. For the somatotropin assay, reaction conditions include a borate/bovine serum albumin buffer (pH 8.4) AND 20-H Incubation at 4 degrees C. Assay results for clinical samples compared favorably (correlation coefficient = 0.930) with values obtained fr...

Aging has been associated with declines in somatotropin and IGF-I levels as well as declines in immune function. To determine the effects of age and whether ST administration could reverse immunosenescence in horses, eight young and eight aged female standardbred horses were given 10 mg/d recombinant equine somatotropin (eST) or vehicle buffer for 49 d. Plasma IGF-I concentrations in both age g...

The risk of growth hormone on cancer in adult with growth hormone deficiency remains unclear. We carried out a meta-analysis to evaluate the risk of cancer in adult with and without growth hormone replacement therapy. We searched PubMed, Web of Science, China National Knowledge Infrastructure, and WanFang databases up to 31 July 2016 for eligible studies. Pooled risk ratio (RR) with 95% confide...

Catch-up growth of 26 children with growth hormone deficiency during four years of growth hormone treatment, which was started young (< 3 years), was compared with that of 16 children with coeliac disease on a gluten free diet. In children with growth hormone deficiency mean (SD) height SD score increased from -4.3 (1.8) to -1.9 (1.4) and in patients with coeliac disease from -1.8 (0.9) to -0.1...

Accessible online at: www.karger.com/hre When discussing total pubertal growth, it is essential that the times of onset and completion of puberty are defined accurately. For example, Gasser and colleagues [1] studied growth curves from boys and girls and defined the onset of puberty as the nadir of growth velocity (i.e. zero growth acceleration). The end of puberty was defined as the point of m...