The complexity of the Bandpass problem is re-investigated. Specifically, we show that the problem with any fixed bandpass number B ≥ 2 is NP-hard. Next, a row stacking algorithm is proposed for the problem with three columns, which produces a solution that is at most 1 less than the optimum. For the special case B = 2, the row stacking algorithm guarantees an optimal solution. On approximation,...

The crystal structures of highly-ordered Mg-Zn-Y long-period stacking-ordered (LPSO) phases with the 18R, 14H and 10H-type stacking sequences have been investigated by atomic-resolution scanning transmission electron microscopy (STEM) and transmission electron microscopy (Kishida et al., 2015) [1]. This data article provides supporting materials for the crystal structure analysis based on the c...

Base-stacking is a key factor in the energetics that determines nucleic acid structure. We measure the tensile response of single-stranded DNA as a function of sequence and monovalent salt concentration to examine the effects of base-stacking on the mechanical and thermodynamic properties of single-stranded DNA. By comparing the elastic response of highly stacked poly(dA) and that of a polypyri...

AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained unresolved, due to the co-existence of multiple different G-quadruplex conformations. We identified a DNA sequence named AT11, derived from AGRO100, which formed a single major G-quadruplex conformation and exhibited a similar anti...

This paper discusses the use of Distance based optimal designs in the design of experiments (DOE) and artificial neural networks (ANN) in optimizing the stacking sequence for simply supported laminated composite plate under uniformly distributed load (UDL) for minimizing the deflections and stresses. A number of finite element analyses have been carried out using Distance-based optimal design, ...

The finite element analysis is adopted in this primary study. Using the Tsai-Wu criterion and delamination criterion, the stacking sequence [45/04/−454/904]s is the final optimal design for the wheelchair frame. On the contrary, the uni-directional laminates, i.e. [9013]s, [4513]s and [−4513]s, are bad designs due to the higher failure indexes. Keywords—Wheelchair frame, stacking sequence, fail...

Synthetically derived trimethylene interstrand DNA cross-links have been used as surrogates for the native cross-links that arise from the 1,N(2)-deoxyguanosine adducts derived from alpha,beta-unsaturated aldehydes. The native enal-mediated cross-linking occurs in the 5'-CpG-3' sequence context but not in the 5'-GpC-3' sequence context. The ability of the native enal-derived 1,N(2)-dG adducts t...

G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solution. It comprises two identical propeller-type parallel-stranded G-quadruplex subunits each contain...