Departments of 1Genetics and 2Pathology, and 3Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA; 4Departments of Pathology and Clinical Laboratories, Memorial Sloan-Kettering Cancer Center, New York, NY; 5Department of Pediatrics, Stanford University, Stanford, CA; 6Department of Basic Medical Sciences, Purdue University, West Lafayette, IN; and 7Hudso...

Stem Cell Group, Nordic EMBL Partnership, Centre for Molecular Medicine Norway (NCMM), University of Oslo, Oslo, Norway City University of Hong Kong, Kowloon, Hong Kong Center for Mitochondrial Medicine and Free Radical Research, Changhua Christian Hospital, Changhua City, Taiwan Biotechnology Centre, Silesian University of Technology, Gliwice, Poland Mackay Medical College, New Taipei City, Ta...

There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard Type DM, transplanting a whole pancreas or its islets has gained attention of researchers in last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing ? cells most notable advancement cure DM. Howeve...

objective: the aim of this study was to estimate the cheminformatics and qualitative structure-activity relationship (qsar) of cinnamaldehyde and eugenol. the effects of cinnamaldehyde and eugenol on the viability, doubling time and adipogenic or osteogenic differentiations of human adipose-derived mesenchymal stem cells (hascs) were also investigated.  materials and methods: qsar and toxicity ...

objective(s): in order to grow cells in a three-dimensional (3d) microenvironment, self-assembling peptides, such as puramatrix, have emerged with potential to mimic the extracellular matrix. the aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

objective: menstrual blood stromal stem cells (mbscs) share some phenotypic and functional similarities with mesenchymal stem cells (mscs). mscs are shown to inhibit either the function or generation of different immune cells, including dendritic cells (dcs). however, data regarding mbscs’ potential effects on immune system cells are elusive. here, we examine whether mbscs affect the generation...

human bone marrow derived mesenchymal stem cells (hbmscs) have the potential to differentiate into cells such as adipocyte, osteocyte, hepatocyte and endothelial cells. in this study, the differentiation of hbmscs into endothelial like-cells was induced in presence of vascular endothelial growth factor (vegf) and insulin-like growth factor (igf-1). the differentiated endothelial cells were exam...

Induced pluripotent stem (iPS) cell technology offers an unprecedented opportunity to study patient-specific disease. This biotechnology platform enables recapitulation of individualized disease signatures in a dish through differentiation of patient-derived iPS cells. Beyond disease modeling, the in vitro process of differentiation toward genuine patient tissue offers a blueprint to inform dis...

high-dose chemotherapy and autologous stem cell transplantation (sct) have become an effective care for many patients with hematological malignancies. harvesting the stem cells is one the most important parts of sct. the two most commonly used mobilization regimens are the use of granulocyte colony-stimulating factor (g-csf) or g-csf plus chemotherapy. however, about 10-30% of patients are unab...