despite the role of oral corticosteroids in management of sever asthma, use of these drugs needs careful awareness of its many side effects. there are controversies about the role of methotrexate in lowering the need for corticosteroides in these patients. in this study an attempt has been made to determine methotrexate effects in corticosteroid dependent asthma. six patients were entered in a ...

Purpose: Idiopathic nephrotic syndrome (INS) is a common glomerular disease observed in children. Depending on their response to steroids, patients can be classified either as having steroid-sensitive (SSNS) or steroid-resistant (SRNS). Whereas SSNS respond favorably steroid treatment and achieve complete remission with normal renal functions, SRNS do not, are at high risk of developing end-sta...

BACKGROUND In Switzerland, the first course of intravenous steroids for treatment of episodes of demyelinating CNS disease is usually administered in an inpatient setting. We prospectively evaluated short term tolerance of treatment with special emphasis on sleep quality. METHODS Patients with a first event of presumed demyelinating disease (CIS), multiple sclerosis relapses (MS) or sub-acute...

PURPOSE This study investigated clinical values of corticosteroid (CS) receptor α and β in the nasal mucosa of patients with allergic rhinitis (AR) by determining CS receptor α and β mRNA expression following steroid treatment. PROCEDURES Among 120 outpatients, 65 had persistent AR, including 36 being sensitive to steroid treatment (steroid-sensitive group) and 29 being resistant to steroid t...

purpose: to evaluate the incidence of steroid-induced ocular hypertension (oht) after myopic photo-refractive keratectomy (prk). methods: myopic prk was performed on 506 eyes of 269 patients. refractive error was between -1.00 and -5.00 diopters of sphere and less than 4 diopters of cylinder. baseline intraocular pressure (iop) before the operation and at different time intervals after the oper...

BACKGROUND AND OBJECTIVES This study aimed to investigate prognostic factors in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). SUBJECTS AND METHODS From January 2007 to December 2011, a retrospective chart review identified 494 consecutive patients with ISSNHL. Demographic, audiometric, and clinical data were analyzed using a logistic regression test. RESULTS Hearing r...

INTRODUCTION. Childhood idiopathic nephrotic syndrome is characterized by frequent relapsing courses or steroid dependency. Levamisole is a popular drug for treatment of these patients. The purpose of this study was to evaluate levamisole in children with steroid-dependent nephrotic syndrome. MATERIALS AND METHODS. We retrospectively studied 304 children with a diagnosis of steroid-dependent ne...