Desmoplasia is a highly aggressive histopathologic feature of cutaneous squamous cell carcinoma CSCC independently associated with death from CSCC. It the deposition abnormal collagen around tumor as seen on H&E. However, structure this unknown. Herein, early immunofluorescence (IF) studies to define differences between normal and desmoplastic structures are reported. Tumor samples 27 patients ...

AIMS The reported incidence of metastasis from squamous cell carcinoma (SCC) of the skin and lip varies between 0.5% and 16%. Clinical and histopathological criteria have been proposed to identify tumours that may have an increased risk of metastasis. The aim of this study was to define such high-risk tumours, especially since the incidence of SCC of the skin is increasing. METHODS AND RESULT...

The importance of the stromal compartment in the development, proliferation, invasion, metastasis and resistance of epithelial cancers has increasingly been recognized in recent decades [1, 2]. This stromal reaction is found in many carcinomas, e.g. in breast, prostate, colon, ovarian and pancreatic cancer. It is made up of stromal cells, endothelial cells, immune cells and extracellular matrix...

Pancreatic stellate cells (PSC), which are implicated in desmoplasia in pancreatic cancer, enhance the malignancy of cancer cells and confer resistance to established treatments. We investigated whether the antifibrotic agent pirfenidone can suppress desmoplasia and exert antitumor effects against pancreatic cancer. Primary PSCs were established from pancreatic cancer tissue obtained during sur...

OBJECTIVE To analyze risk factors for neck metastases in patients with parotid carcinomas. DESIGN Cohort of patients followed up from 1 to 366.2 months at a single institution. SETTING Referral center, private or institutional practice, hospitalized care. PATIENTS A total of 145 patients with parotid carcinomas with complete clinical and pathological information. The histological diagnosi...