desmoplastic ameloblastoma is a rare variant of ameloblastoma. up until now, less than 150 patients have been reported in the literature. we report a case of desmoplastic ameloblastoma in a 45-year-old female with a painless swelling in the left anterior maxillary region. fine needle aspiration yielded no fluid. periapical and panoramic radiographs as well as computer tomography scan showed a m...

Desmoplasia--the presence of a rich stroma around a tumor--has long been associated with a poor clinical outcome in patients with cancer. It is considered to be a response to the presence of invasive tumor cells. There is now evidence that desmoplasia is the result of coordinated changes in several stromal cells under the control of a single gene product, CD36, whose repression leads to a decre...

Clinical studies have shown that decreased tamoxifen effectiveness correlates with elevated levels of vascular endothelial growth factor (VEGF)-A(165) in biopsy samples of breast cancers. To investigate the mechanisms underlying tamoxifen resistance and metastasis, we engineered the estrogen receptor (ER)-positive MCF-7 human breast cancer cell line to express VEGF to clinically relevant levels...

BACKGROUND To evaluate the pathological characteristics of invasive margins in early-stage cervical squamous cell carcinomas and their association with other clinicopathological features including clinical outcomes. MATERIALS AND METHODS Patients with FIGO stage IB-IIA cervical squamous cell carcinomas who received surgical treatment and had available follow-up information were identified. Th...

PURPOSE Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of fibrosis, termed desmoplasia, which is thought to hamper the efficacy of therapeutics treating PDAC. Our primary focus was to evaluate differences in the extent of desmoplasia in primary tumors and metastatic lesions. As metastatic burden is a primary cause for mortality in PDAC, the extent of desmoplasia in meta...

Pancreatic ductal adenocarcinoma [PDAC] continues to be associated with a dismal prognosis with 5-year survival rates consistently less than 5% [1]. One of the main histopathological features of PDAC is the abnormal deposition of stromal fibrosis, also known as desmoplasia. It constitutes the tumor microenvironment in which various sub-populations of the innate and adaptive immune system are di...

The desmoplastic reaction is a prominent pathological characteristic of pancreatic cancer. Desmoplasia is marked by a dramatic increase in the proliferation of alpha-smooth muscle actinpositive fibroblasts and is also accompanied by increased deposition of many extracellular matrix components. Changes in stromal cell proliferation and the deposition of extracellular matrix components result in ...

Pancreatic cancer (PaCa) is characterized by dense stroma that hinders treatment efficacy, with pancreatic stellate cells (PSCs) being a major contributor to this stromal barrier and PaCa progression. Activated PSCs release hepatocyte growth factor (HGF) insulin-like (IGF-1) induce proliferation, metastasis resistance chemotherapy. We demonstrate for the first time suppressor, N-myc downstream ...

Clinically, pancreatic tumors have proven to develop resistance to available treatment options; however, efficacy might be achieved if the required levels of drugs reach the tumor site. Tumor microenvironment (TME) leads to extensive desmoplasia and chemo-resistance, contributing immensely to the invasive and metastatic process of pancreatic carcinoma [1]. Desmoplasia involves the excessive pro...