An accurate, reproducible colorimetric method for determining minute amounts of alkylating agents in biologic fluids has been developed. Utilizing this method, we have been able to detect less than 0.1 g. of nitrogen mustard (HN2), or Thio-TEPA in 1 ml. of plasma, lymph, urine, or tissue homogenate. The biologic fluid was deproteinized with zinc sulfate, barium hydroxide, and methanol; the supe...

Following the demonstration of the effective ness of triethyleneimino-s-triazine (TEM) in the treatment of experimental tumors and of its clini cal value in the management of certain types of malignant disease, a series of ethyleneimino deriv atives was synthesized. An evaluation of their carcinostatic effects revealed that triethylenephosphoramide (TEPA), an ethyleneimine-substituted phosphori...

After phenylmaleimido group was successfully incorporated into bisphenol-A type epoxy resins (B-13 ) to result in compound possessing both oxirane ring and maleimide reactive groups. The cured maleimide epoxy samples are obtained by thermally curing of the maleimide epoxy (MIE) compounds with aliphatic long chained amines such as Tetraethylenepentamine (TEPA), Bishexamethylenetriamine (BHMT), 2...

Abstract High-surface-area, hexagonal-structured mesoporous silica, MCM-41, was synthesized and wet impregnated with three different amines of 2-(ethylamino) ethanol (EAE), ethylenediamine (EDA), tetraethylenepentamine (TEPA) for use as solid adsorbents in post-combustion CO2 capture application. The adsorption test performed at 25°C atmospheric pressure using 15/85 vol% CO2/N2 a 20-mL/minute f...

In this work, a new synthesized Y-type zeolite with an Si/Al molar ratio of 2.5 (NaY) was modified with amines, in order to probe the influence of the modification of the adsorbent’s surface on CO2 adsorption. The three selected amines were diethanolamine, tetraethylenepentamine, and 2- methylaminoethanol. The surface nature of NaY was changed after amine modification, which causes a...

Abstract – The basics of two domain decomposition methods based on the surface equivalence principle and the method of moments, namely, the surface tangential equivalence principle (TEPA) and the linear embedding via Green’s operators (LEGO), are outlined to solve electromagnetic scattering problems. In order to efficiently solve large problems, the methods are combined with the characteristic ...

Pentoxifylline potentiates the cytotoxicity of alkylating agents in preclinical models. In this study we sought to define the maximum tolerated dose (MTD) of N,N',N"-triethylenethiophosphoramide (thioTEPA) with pentoxifylline, and to estimate the antitumor response to this combination in previously treated breast cancer patients. Thirty-five previously treated advanced breast cancer patients re...