Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the CNS. Initially, IFN-gamma-producing Th1 cells and, more recently, IL-17-producing Th17 cells with specificity for myelin Ags have been implicated in EAE induction, but whether Th17 cells are encephalitogenic has been co...

Background: Random induced mutation by gamma radiation is one of the genetic manipulation strategies to improve the antagonistic ability of biocontrol agents. Objectives: This study aimed to induce mutants with more sporulation, colonization rate leading to enhanced antagonistic ability (in vitro assay) comparing to wild type (WT) and the assessment of genetic differences (in situ evaluat...

macrophomina phaseolina is one of the major yield limiting factors of melons in tropical and subtropical regions. for eco-friendly and effective management of the disease, 24 gamma induced mutants from trichoderma harzianum were evaluated against three isolates of the pathogen representing three geographically different regions viz. khorasan (isolate 1), garmsar (isolate 2) and khuzestan (isola...

Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immunity. Atherosclerotic lesions contain a variety of cells including smooth muscle cells, macrophages, and T lymphocytes, as well as other inflammatory cells, such as mast cells and NKT cells. This collection of cells promotes the development of atherosclerosis through the production of inflam...