نتایج جستجو برای: thalassemia minor

تعداد نتایج: 102111  

Journal: :Journal of Korean Medical Science 1992
N. Y. Lee H. I. Cho S. I. Kim B. K. Kim Y. Ohba Y. Hattori

We report a Korean family case of beta-thalassemia minor and Hb Queens. This is the first case report of Hb Queens in Korea. A 43-year-old male and his four family members had beta-thalassemia minor which is very rare in Korea. Incidentally, an alpha chain variant with a high isoelectric point was also found in two other family members without clinical problems and was finally identified as alp...

Journal: :Blood 1979
J D Bessman D I Feinstein

The coefficient of variation (CV) of red cell size, as measured by electronic red cell sizing (erythrography), was less than 14.0% in 20 normal subjects. In 22 of 25 patients with beta-thalassemia minor and microcytosis (mean corpuscular volume [MCV] less than 70 fl), CV was less than 14.0%; in the other 3, CV was 14.0%--14.9%. In 53 patients with iron deficiency anemia and MCV less than 70 fl,...

Journal: :The Journal of clinical investigation 1971
G D Efremov R N Wrightstone T H Huisman W A Schroeder C Hyman J Ortega K Williams

A Chinese family with hemoglobin H in the propositus has been reinvestigated. Although the original propositus is now deceased, a sister has the same hematological manifestations. Her hemoglobin, like that of the deceased sister, contains hemoglobins A, H, and Bart's. In addition, however, two minor components have been detected. These minor components appear to have abnormal alpha-chains and a...

2017
Parth S Shah Nidhi D Shah Hari Shankar P Ray Nikunj B Khatri Ketan K Vaghasia Rutvik J Raval Sandip C Shah Mandava V Rao

BACKGROUND β-Thalassemia is the most prevalent genetic disorder in India. Its traits and coinheritance vary from mild to severe conditions, resulting in thalassemia minor, intermediate, and major, depending upon many factors. PURPOSE The objective of this study was to identify the incidence of β-thalassemia traits, their coinheritance, and mutations, as well as to support the patients already...

H Hashemizadeh , R Noori ,

Abstract Background Beta thalassemia is a preventable disease. Iran has about 20,000Patients who are homozygote for β-thalassaemia and 3,750,000 carriers. The aim of this study was to determine the prevalence of beta thalassemia minor among men who underwent premarital screening in Quchana city in Khorasan Razavi region of Iran Materials and Methods This research is a descriptive cross-sect...

Background: Thalassemia is the most prevalent genetic disorder in humans. It is caused by the deficient or lack of production of one of the globin chains. The present study aimed to evaluate the performance indicators of Behbahan Health Center, Iran in terms of the prevention of thalassemia major during 2006-2016. Methods: This descriptive, cross-sectional study was conducted on the couples re...

حسینی , سیدحمزه, سلجوقیان , آناهیتا, ضرغامی , مهران, غفاری ساروی , وجیهه,

Background and purpose: Previous studies indicate an important genetic factor in the etiology of β-Thalassemia and bipolar mood disorder. There has been several case reports implicating a possible association between the two conditions. But the results of a cross sectional study was not reconfirming. Regarding different patterns of mutations in different geographical areas, this study was per...

2010
P. Lahiry

Beta-thalassemia is one of the most prevalent autosomal disorders in the world. Mutations in the HBB gene underlie deficiencies in hemoglobin production, which can interfere with oxygen delivery resulting in wide range of disease severity. Although >535 mutations have been characterized in the HBB gene, beta-thalassemia is broadly classified into three groups, based on clinical severity: beta-t...

Journal: :Archives of medical research 2008
Mehran Karimi Majid Yavarian Abdolreza Afrasiabi Javad Dehbozorgian Eliezer Rachmilewitz

BACKGROUND beta-thalassemia is the most common inherited single gene disorder worldwide, and glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency. The goal of this study was to compare the frequency of beta-thalassemia trait and G6PD among the Moslem and Jewish populations in Shiraz, southern Iran. METHODS We examined 201 Moslems and 187 Jewish subjec...

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