In this paper, a hybrid learning model of imbalanced evolving self-organizing maps (IESOMs) is proposed to address the imbalanced learning problems. In our approach, we propose to modify the classic SOM learning rule to search the winner neuron based on energy function by minimally reducing local error in the competitive learning phase. The advantage of IESOM is that it can improve the classifi...

The majority of cortical interneurons use GABA (gamma amino butyric acid) as inhibitory neurotransmitter. GABAergic neurons are morphologically, connectionally, electrically and chemically heterogeneous. In rat cerebral cortex three distinct groups of GABAergic interneurons have been identified by the expression of parvalbumin (PV), calretinin (CR) and somatostatin (SOM). Recent studies in mous...

A rational drug design approach involving transposition of functional groups from SRIF into a reduced size cyclohexapeptide template has led to the discovery of SOM230, a novel, stable cyclohexapeptide somatostatin mimic which exhibits unique high affinity binding to human somatostatin receptors (sst1-5). This unique receptor subtype binding profile, in particular the exceptional high affinity ...

Gastrin-releasing peptide (GRP) can stimulate both gastrin and somatostatin (SOM) secretion, but, as gastrin increases SOM and SOM in turn inhibits gastrin, the overall endpoint in terms of gastrin output is variable. To examine the mechanisms involved, we compared the effects of GRP on gastrin secretion in normal sheep and sheep chronically immunized against SOM. In the normal animal, GRP had ...

objective(s):this study examined whether conjugated linoleic acid (cla) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (ppar-γ) and glucose transporter type 4 (glut-4) protein expressions in the skeletal muscles of rats during endurance exercise. materials and methods:sprague-dawley male rats were randomly divided into hs (high-fat diet (hfd) se...

PURPOSE To detect the presence of somatostatin (SOM) in normal aqueous humor and to characterize its immunosuppressive activity. METHODS Fresh rabbit aqueous humor was assayed for SOM by competitive ELISA. Primed T cells stimulated through their T-cell receptor (TCR) were treated with SOM at concentrations that ranged the level of SOM found in normal aqueous humor. The T cells were assayed fo...

In this paper a new tool for visualizing self organizing maps (SOM) for interdisciplinary explorative data analysis is proposed, the SOM reef. By combination of the U-matrix visualization approach with the new introduced fish glyph, the SOM can be displayed as a underwater scenario. Data sets can be visualized in the SOM as swarms of fishes or prototypes. The SOM reef provides (i) a powerful me...