The complement alternative pathway is a powerful arm of the innate immune system that enhances diverse inflammatory responses in the human host. Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and positively regulate alternative pathway activity. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers o...

Introduction. Thrombosis is a formidable complication of the oncological process that still profoundly contributes to overall mortality despite anticoagulant use. According recent data, thrombosis in cancer represents special type prothrombotic state, wherein thromboinflammationis one its constituents. In addition, thromboinflammation both disease progression and intensity metastasis processes....

One of the most dangerous features new coronavirus infection caused by SARS-CoV-2 virus is tendency hemostasis system patients to excessive thrombus formation. Among possible causes this pathology, both activation vascular endothelial cells, leading exposure tissue factor these and direct plasma were named. Besides, there a significant change in platelet responses activation, which not accompan...

Introduction. Coronavirus infection is associated with severe endotheliopathy, thromboinflammation and immunothrombosis leading to excessive release of von Willebrand factor (vWF) multimers from Weibel–Palade bodies, which can affect activity ADAMTS-13 metalloproteinase (a disintegrin thrombospondin type 1 motif, member 13) the ADAMTS-13/vWF axis previously shown by us be altered in non-pregnan...