We have developed the first chondroitin sulfate polymer coated gold nanoparticles that can simultaneously overcome mulidrug resistance in cancer cells and suppress thromboinflammation triggered by the chemotherapeutic drug.

Delayed cerebral ischemia (DCI) is a major determinant of patient outcome following aneurysmal subarachnoid hemorrhage. Although the exact mechanisms leading to DCI are not fully known, inflammation, cerebral vasospasm, and microthrombi may all function together to mediate the onset of DCI. Indeed, inflammation is tightly linked with activation of coagulation and microthrombi formation. Thrombo...

To the Editor: The recent article by Na et al shows that amplification of regulatory T-cell (Treg) improves stroke outcome in both permanent and transient mechanical vascular occlusion (TMVO) models in mice. Surprisingly, Schuhmann et al published the exact opposite finding 1 month before, ie, amplification of Treg worsens stroke outcome by increasing thromboinflammation. One year after publica...

To the Editor: The recent article by Na et al shows that amplification of regulatory T-cell (Treg) improves stroke outcome in both permanent and transient mechanical vascular occlusion (TMVO) models in mice. Surprisingly, Schuhmann et al published the exact opposite finding 1 month before, ie, amplification of Treg worsens stroke outcome by increasing thromboinflammation. One year after publica...

OBJECTIVE It is known that both platelets and coagulation strongly influence infarct progression after ischemic stroke, but the mechanisms and their interplay are unknown. Our aim was to assess the contribution of the procoagulant platelet surface, and thus platelet-driven thrombin generation, to the progression of thromboinflammation in the ischemic brain. APPROACH AND RESULTS We present the...

BACKGROUND Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute ischemic stroke. Using intravital microscopy, we investigated and characterized the sequence of downstream microvascular thromboinflammation in an ischemia/reperfusion acute ischemic stroke model. METHODS AND RESULTS Rats underwent transient monofilament...

The main goal of ischemic stroke treatment is rapid recanalization of the occluded blood vessel to limit brain injury and to salvage threatened cerebral tissue. To achieve early vessel recanalization, thrombolysis using recombinant tissue-type plasminogen activator is currently the only approved pharmacological intervention. Only recently, endovascular therapy has made its way into the clinic e...

Abstract Thromboinflammation is the major cause of morbidity and mortality in COVID-19 patients, post-mortem examination demonstrates presence platelet-rich thrombi microangiopathy lung other visceral organs. Moreover, persistent microclots were detected both acute long COVID plasma samples. However, molecular mechanism SARS-CoV-2-induced thromboinflammation still unclear. We found that spleen ...