Psoriasis is a common chronic, recurrent, immune-mediated disease of the skin and joints. In psoriasis, epidermal hyperproliferation, abnormal keratinocyte differentiation, angiogenesis with blood vessel dilatation excess Th-1 Th-17 infiltration can be observed. A broad spectrum anti-psoriatic treatments, both topical systemic, are available for management psoriasis. However, there still no cur...

Combinations of lecithin with hydrophilic (e.g. C8-PEG) and lipophilic (e.g. sorbitan monooleate) linkers (unbalanced amphiphiles) have been used to produce microemulsions with a wide range of oils. The resulting microemulsions have been found to be biocompatible through a number of tests, including cell viability tests, Human Repeat Insult Patch Test (HRIPT), and Ames test. In this presentatio...

Objective: The present research was aimed to develop ketoconazole (KT) loaded microemulsion-based gel formulation for effective topical delivery through enhanced drug solubility, improved skin permeation and reduced side effects overcoming drawbacks of conventional dosage forms. Methods: For the selection oil, surfactant co-surfactant mixture (Smix) ratio, phase titration method used pseudo-ter...

We predict, qualitatively, the structural transitions in microemulsion systems induced by nonionic polymers, by virtue of their ability to associate with the surfactant assemblies. The predictions are made possible by linking (a) theoretical calculations of the domains of existence of oil-in-water (O/W) and water-in-oil (W/O) droplet microemulsions with (b) the experimental observation that on ...

  Objective(s): The objective of this study was to design a topical microemulsion of Vit B12 and to study the correlation between internal structure and physicochemical properties of the microemulsions. Microemulsions are thermodynamically stable mixtures of water, oil, surfactants and usually cosurfactants with several advantages for topical and transdermal drug delivery. The formul...

BACKGROUND A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs. METHODS The microemulsion formulation was optimized using a pseudoternary phase diagram, comprising ...

objective(s): the objective of this study was to design a topical microemulsion of vit b12 and to study the correlation between internal structure and physicochemical properties of the microemulsions. microemulsions are thermodynamically stable mixtures of water, oil, surfactants and usually cosurfactants with several advantages for topical and transdermal drug delivery. the formulation of micr...