BACKGROUND Cognitive functioning in individuals with Obsessive Compulsive Disorder (OCD) and with Obsessive Compulsive Personality Disorder (OCPD) has not been adequately studied. AIM Examine the cognitive flexibility and planning ability of individuals with OCD and OCPD. METHODS Twenty patients with OCD and 25 patients with OCPD who had not taken medication in the previous two weeks were i...

The Tower of London task (TOL) has been widely used to assess the ability to plan. We used H(2)O(15)-positron emission tomography to isolate some of the cognitive components of the task. Ten male volunteers were scanned twice in each of six conditions. In two conditions (plan) the subjects had to plan the best solution to TOL problems. In two other conditions (plan-control) the subjects were re...

We used the Tower of London task (TOL) and H(2)(15)O-PET to map the network of brain structures involved in planning. Six healthy right-handed subjects had 12 measurements of relative regional cerebral blood flow (rrCBF) during six conditions, each performed twice. There was one rest condition, and five sets of TOL problems at different complexity levels, performed on a touch-sensitive computer...

In traditional cognitive science, cognition amounts to symbol manipulation (Newell and Simon, 1972). Symbol manipulation is the processing of symbolic descriptions to produce an output that benefits an objective. Moreover, embodied models of cognitive development concern situated robots that do not rely on symbolic descriptions or on their manipulation (see, e.g., (Schlesinger, 2003)). In this ...

Alzheimer’s disease (AD) is associated with progressive impairment of higher-level cognitive abilities. Previous research suggests that early impairment of executive functions occurs during the course of the disease, but few studies have specifically investigated planning ability in an AD population. Objective: The purpose of the current study was to examine whether AD patients retain the abili...

This computer model was commissioned by the Tower Environs Partnership as part of the technical studies to underpin proposed enhancement of the surroundings of the Tower. It is intended to provide a sufficiently fine-grained photo-realistic facsimile to allow fine judgement of minor changes in landscape detail. Its credibility is underpinned by close correspondence to the original survey data a...

† Department of Mathematics, King’s College London, The Strand, London WC2R 2LS, United Kingdom ‡ Randall Division of Cell and Molecular Biophysics, King’s College London, New Hunts House, London SE1 1UL, United Kingdom § London Institute for Mathematical Sciences, 35a South St, Mayfair, London W1K 2XF, United Kingdom ⋆ Department of Medical and Molecular Genetics, King’s College London School ...

Previous research has shown drug-free Ecstasy users to demonstrate selective cognitive impairment. However, there seems to be a degree of individual variation in the occurrence of such deficits. The present study aimed to assess whether these cognitive deficits are related to an awareness of problematic Ecstasy use, or to past drug dosage. Twenty regular Ecstasy users who reported experiencing ...