This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detection is 25 to 800 micrograms/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 micrograms/L for both drugs was approximately 10%. Accuracy (relative error) in the same concen...

21, 1996. Reprint requests: Dr. Partinen, Haaga Centre for Neurologic Research and Rehabilitation, M1dkipellontie 15, FIN-00320 Helsincki Finland In a recent study by Young et al,' 2% of women and 4% of men in the middle-aged workforce met the diagnostic criteria for OSAS. Currently various therapeutic approaches for the management of OSAS are available. Conservative management consists of weig...

OBJECTIVE To evaluate and permanently improve axillary hyperhidrosis. BACKGROUND Excessive sweating of the axillae is a common problem for which patients frequently seek dermatologic advice and therapy. Many treatments, including aluminum chloride, topical and systemic anticholinergic agents, tranquilizers, iontophoresis, direct surgical excision, botulinum toxin injection, and thoracic sympa...

serotonin in platelets or other organs. Giarman and Schanberg (Biochem. Pharmacol. 1:301, 1959) showed that iproniazid does indeed hinder reserpine-induced release of serotonin from storage granules in rat's brain. Recently, the same has been found to be true about release of catecholamines from rabbit's atria. These objections and criticisms are raised here only to present one of the apparent ...