Transcranial Direct Current Stimulation (tDCS) is a non-invasive, low-cost, well-tolerated technique producing lasting modulation of cortical excitability. Behavioral and therapeutic outcomes of tDCS are linked to the targeted brain regions, but there is little evidence that current reaches the brain as intended. We aimed to: (1) validate a computational model for estimating cortical electric f...

Transcranial direct current stimulation (tDCS) has been applied in numerous scientific studies over the past decade. However, the possibility to apply tDCS in therapy of neuropsychiatric disorders is still debated. While transcranial magnetic stimulation (TMS) has been approved for treatment of major depression in the United States by the Food and Drug Administration (FDA), tDCS is not as widel...

Objectives: Parkinson’s disease (PD) has been associated with impaired motor sequence learning (also known as procedural learning). In the current study, we determined the potential of anodal transcranial direct current stimulation delivered over the primary motor cortex to promote the acquisition of sequential movement in a large sample of patients with idiopathic PD and matched controls. Meth...

Transcranial Electrical Stimulation: Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS), Transcranial Pulsed Current Stimulation (tPCS), andTranscranial Random Noise Stimulation (tRNS) Ingrid Moreno-Duarte, Nigel Gebodh, Pedro Schestatsky, Berkan Guleyupoglu, Davide Reato, Marom Bikson, and Felipe Fregni Laboratory of Neuromodulation, Department ...

The transcranial application of weak currents to the human brain has enjoyed a decade of widespread use, providing a simple and powerful tool for non-invasively altering human brain function. However, our understanding of current delivery and its impact upon neural circuitry leaves much to be desired. We argue that the credibility of conclusions drawn with transcranial direct current stimulatio...

BACKGROUND The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and reduce perceived pain, can be increased following transcranial direct current stimulation of the hand motor cortex. Using high-definitio...