The main theme of this thesis is to investigate the origins of photosensitizer pharmacokinetic variability, how this pharmacokinetic variation affects photodynamic therapy (PDT), and to search for innovative strategies to reduce the inter-individual pharmacokinetic variability and variability in treatment response. PDT involves photosensitizer administration and light irradiation to the tissue ...

BACKGROUND AND PURPOSE To correlate changes of various CT parameters after the neoadjuvant treatment in patients with lung adenocarcinoma with pathologic responses, focused on their relationship with different therapeutic options, particularly of EGFR-TKI and concurrent chemoradiation therapy (CCRT) settings. MATERIALS AND METHODS We reviewed pre-operative CT images of primary tumors and surg...

Recent advances in Stereotactic Radiosurgery/Conformal Radiotherapy have made it possible to deliver surgically precise radiation therapy to small lesions while preserving the surrounding tissue. However, because of physiologic motion, the application of conformal radiotherapy to extra-cranial tumors is, at present, geared toward slowing the progression of disease rather than obtaining a cure. ...

OBJECTIVE The aim of this study was to explore the relation between preoperative tumor size based on magnetic resonance imaging (MRI) and the surgical pathologic staging parameters (deep myometrial invasion, cervical stroma invasion, and metastatic lymph nodes) and to assess the prognostic impact of tumor size in endometrial carcinomas. Interobserver variability for the different tumor size mea...

objectives this study aimed at reviewing the current literature on the diagnosis, staging, and different treatment strategies for wilms’ tumor with either ureteral or intravascular extension. evidence acquisition in this article, we reviewed the current literature about staging, diagnosis, and management strategies for wt, through a randomized clinical trial, which focused on this matter. the m...

calcifying fibrous tumor (cft) is a rare mesenchymal tumor, affecting children and young adults with a predilection for the soft tissue and the abdominal cavity. cft of the tubular gastrointestinal tract is very rare with less than 20 cases of gastric cfts reported in english literature. this benign hypocellular fibrosclerotic calcifying lesion can resemble other spindle cell tumors particularl...

purpose : to review periocular dermoid cysts to determine distribution of demographic factors, and tumor location methods : in this retrospective, observational case series in a tertiary-care hospital, we reviewed all cases of histopathologically verified periocular dermoid cysts at our institution between 2003 and 2011. the study endpoints included: age, gender, and tumor location. results : t...