This study investigated efficacy and side effects of Morphine suppository for pain management after the first elective caesarean delivery in comparison to Diclofenac suppository. One hundred women aged 18-40 with term pregnancies undergoing elective caesarean section for the first time participated in this prospective project. Exclusion criteria included drug sensitivity, fetal malformations or...

UNLABELLED Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from omega-3 fish oil. Our purpose was to evaluate the safety of marine lipid supp...

Purpose: To use differential scanning calorimetry (DSC) to predict the liquefaction time and dissolution profile of some commercial paracetamol suppositories as well as paracetamol suppositories formulated with palm oil base. Methods: The suppository base was prepared by mixing hydrogenated palm oil and palm kernel stearin in a ratio of 8:2. Three commercial paracetamol suppositories (A, B, and...

background: preterm birth is the major cause of neonatal mortality and morbidity. objective: the aim of this study was to evaluate the effect of prophylactic vaginal progesterone on decreasing preterm birth rate and neonatal complications in a high-risk population. materials and methods: a randomized, double-blind, placebo-controlled study was performed on 100 high-risk singleton pregnancies. v...

Miconazole nitrate is an imidazole derivative antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal infections. Over 90% of miconazole nitrate is reported to be bound to plasma proteins. In this study, miconazole nitrate was formulated into bioadhesive vaginal suppositories using different suppository bases such as fat...

STRUCTURE AND DERIVATION oric acid, also called boracic acid or orthoboric acid, is an inorganic acid with the chemical formula H3BO3. It is available as a white, odorless powder and in crystalline and granular forms. Bo-ric acid vaginal suppositories are not commercially available and, therefore, must be compounded. Most studies documenting efficacy utilize 600 mg of boric acid powder in a gel...

Bacterial vaginosis is one of the most common urogenital diseases affecting women in reproductive age. The administration of probiotics as vaginal suppository has been proposed as a strategy to cure this condition and reduce its recurrence. Nonetheless, also oral consumption of probiotics, which is a more practical route of administration, proved to be an efficient strategy. In this perspective...

Microbicides are an active area of research for HIV prevention, being developed as a woman-initiated method of prevention during unprotected coitus. Along with safety and efficacy, assessing and improving compliance is a major area of research in microbicide development. We have produced microbicide prototypes in the form of semisoft vaginal suppositories prepared from carrageenan and conducted...