This study evaluated live performance, carcass, abdominal fat and commercial cuts yields of broilers fed corn-soybean meal diets with increasing digestible valine to lysine levels from 21 to 42 days of age. One thousand five hundred and seventy-five Cobb vs Cobb 500 male broilers were raised with the same commercial mash feed until 21 days of age. Seven treatments with 9 replications of 25 bird...

The potency of L-valine as an inhibitor of Zea mays acetohydroxyacid synthase (AHAS) is increased more than 8000-fold on conversion to its N-phthalyl anilide derivative which is active at 2 microM. The D-valine, alpha-aminobutyric acid, isoleucine and phenylalanine analogs are 11- to 43-fold less potent, and similar N-phthalyl anilide derivatives of other branched-chain amino acids are essentia...

4-Valine-oxytocin and 1-deamino-4-valine-oxytocin, analogues of the posterior pituitary hormone containing a valine residue in place of the glutamine residue in position 4, have been synthesized by the p-nitrophenyl ester method of peptide synthesis and tested for pharmacological activity. The 4-valine-oxytocin possesses 140 units per mg of oxytocic activity and 240 units per mg of avian vasode...

Control of the regulatory enzyme threonine deaminase from Escherichia coli is achieved by isoleucine inhibition and valine activation. The mechanism by which these heterotropic effectors regulate the enzyme was investigated by measuring the binding of isoleucine and valine by spectroscopic, kinetic, calorimetric and equilibrium dialysis techniques. The addition of isoleucine or valine to threon...

The L-valine production strain of Escherichia coli was constructed by rational metabolic engineering and stepwise improvement based on transcriptome analysis and gene knockout simulation of the in silico genome-scale metabolic network. Feedback inhibition of acetohydroxy acid synthase isoenzyme III by L-valine was removed by site-directed mutagenesis, and the native promoter containing the tran...

BACKGROUND The branched chain alcohol isobutanol exhibits superior physicochemical properties as an alternative biofuel. The yeast Saccharomyces cerevisiae naturally produces low amounts of isobutanol as a by-product during fermentations, resulting from the catabolism of valine. As S. cerevisiae is widely used in industrial applications and can easily be modified by genetic engineering, this mi...

Five coordination polymers with the stoichiometry CaX2(valine)2(H2O)2 (X = Cl, Br) were obtained from the corresponding calcium halides and either racemic and enantiopure valine. In all cases the zwitterionic amino acid is exclusively O coordinated and the halides act as counteranions for the resulting one-dimensional cationic chains. The enantiopure chloride shows dimorphism; both forms differ...

Abnormally high and delayed clearance curves of serum valine with the absence of an accumulation of alpha keto-acids in blood following an oral dose of valine were demonstrated in idiopathic hypervalinemia. Normal clearance curves were obtained in the case of oral loading with leucine, isoleucine or methionine. These findings lead us to speculate a possible block in the transamination reaction ...