Sir, I read with much interest the article by Bosch et al. (2010) published recently in the Human Reproduction. In a retrospective analysis, the authors examined the relationship between serum progesterone (P) level on the day of hCG administration (hCG day) and the probability of ongoing pregnancy, in an unselected population of women undergoing controlled ovarian hyperstimulation (COH) for as...

Resistance ovarian syndrome is a heterogeneous disorder inherited as a Mendelian recessive trait and characterized by infertility, primary amenorrhea, normal karyotype and elevated serum FSH and LH levels. An inactivating mutation, C566T, in FSH receptor gene (FSHR) has been identified initially in Finland. We investigated if an adenovirus expressing a normal copy of human FSHR (Ad-hFSHR) has t...

Previous studies from our laboratory, demonstrating that suppression of serum FSH by RU486 requires a high estrogen (E) background, suggested that E-inducible progesterone receptors play a role in the regulation of FSH secretion. We demonstrated further that the type II antiprogestin RU486 and the type I antiprogestin ZK98299 both suppressed the elevated serum FSH and FSHbeta messenger RNA leve...

The patient was a 66-year-old woman, G2P2. The patient presented a chief complaint of irregular postmenopausal bleeding 1 month ago. A transvaginal ultrasonography showed that bilateral ovaries were not enlarged and uterine endometrium was thickened, measuring at 9 mm. As a result of endometrial curettage, the simple endometrial hyperplasia was revealed. A blood examination showed an elevated e...

Estradiol-treated, rat pituitary cells were studied to examine the effects of progesterone (P) on follicle-stimulating hormone (FSH) synthesis and secretion. Progesterone was administered prior to or concurrent with 3 h secretory challenges with either gonadotropin-releasing hormone (GnRH), the iontophore A23187, the protein kinase C activator phorbol 12,13-myristate (PMA), or no secretagogue. ...

OBJECTIVE To measure testicular volume and the gonadotrophin response to gonadotrophin-releasing hormone (GnRH) stimulation in adolescents undergoing left varicocelectomy. PATIENTS AND METHODS Thirteen adolescents undergoing varicocelectomy had their testicular volume and endocrine function evaluated before and after surgery. RESULTS The initial left testicular volume was consistently small...