OBJECTIVES Serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant medications may have efficacy in relieving pain associated with fibromyalgia syndrome (FMS), even in the absence of major depressive disorder (MDD). Current practice is to use a trial-and-error treatment strategy, often requiring 8-12 weeks to determine the effectiveness of a given pharmacological intervention. The abi...

The antidepressant activity of the N-methyl-D-aspartate (NMDA) receptor channel blocker, ketamine, has led to the investigation of negative allosteric modulators (NAMs) selective for the NR2B receptor subtype. The clinical development of NR2B NAMs would benefit from a translational pharmacodynamic biomarker that demonstrates brain penetration and functional inhibition of NR2B receptors in precl...

INTRODUCTION Previous studies of patients with unipolar depression have shown that early decrease of prefrontal EEG cordance in theta band can predict clinical response to various antidepressants. We have now examined whether decrease of prefrontal quantitative EEG (QEEG) cordance value after 1 week of venlafaxine treatment predicts clinical response to venlafaxine in resistant patients. METH...

Objective This study compares the complementary information from semi-quantitative EEG (sqEEG) and spectral quantitative (spectral-qEEG) to detect life-long effects of early childhood malnutrition on brain. Methods Resting-state EEGs ( N = 202) Barbados Nutrition Study (BNS) were used examine protein-energy (PEM) middle adulthood outcomes. sqEEG analysis was performed Grand Total (GTE) protocol...

Manual differentiation of electroencephalography (EEG) paper recordings in cases of depression is not very helpful. So, a Multilayer Perceptron (MLP) has been used to differentiate the EEG power density spectra (qEEG) in the wakeful state from animals (control, exercised and depressed). The qEEG ranging from 1 to 30 Hz, at 1 Hz increments (30 input features) and also a slow, medium and fast act...

The purpose of this study was to investigate the effects of methylphenidate, a psychostimulant, on quantitative electroencephalography (QEEG) during the continuous performance test (CPT) in boys with attention-deficit hyperactivity disorder (ADHD). The QEEG was obtained from 20 boys with ADHD. The amplitudes of 4 bands (alpha, beta, delta, and theta) in the QEEG, as well as the theta /beta rati...

Quantitative electroencephalogram (qEEG) monitors are often used to estimate depth of anesthesia and intraoperative recall during general anesthesia. As with any monitor, the processed numerical output is often misleading and has to be interpreted within a clinical context. For the safe clinical use of these monitors, a clear mental picture of the expected raw electroencephalogram (EEG) pattern...

introduction: the aim of this study is to investigate the entrepreneurial traits of school children in the city of tehran. methods: for this purpose, 48 students were selected with an average iq between 90 and 119. ranging from 7th to 12th grades, all the subjects were assessed using nowicki-strickland’s locus of control scale (n-slcs), torrance tests of creative thinking (ttct), and hyperkinet...

The lowest frequencies are delta. These are less than 4 Hz and occur in deep sleep and in some abnormal processes, also during ex-periences of "empathy state". Delta waves are involved with our ability to integrate and let go. It reflects unconscious mind. It is the dominant rhythm in infants up to one year of age and it is present in stages 3 and 4 of sleep. It tends to be the highest in ampli...