LEGO® presented the following problem at the SCAI’01 conference in February 2001: Given any 3D body, how can it be built from LEGO bricks? We apply methods of Evolutionary Algorithms (EA) to solve this optimization problem. For this purpose several specific operators are defined, applied, and their use is compared. In addition, mutation operators with dynamic rate of mutation updated based on t...

The field of structural heart disease (SHD) intervention has grown rapidly over the past several years. While training program content, standards, credentialing, and board examinations for percutaneous coronary intervention have matured and become well developed, no such structure exists in the field of SHD. Recognition of the need for training program standards and SHD curriculum stimulated th...

PCI WRITING COMMITTEE* Glenn N. Levine, MD, FACC, FAHA, Chair, Eric R. Bates,* MD, FACC, FAHA, FSCAI, Vice Chair, James C. Blankenship,* MD, FACC, FAHA, FSCAI, Vice Chair, Steven R. Bailey,* MD, FACC, FSCAI, John A. Bittl, MD, FACC, Bojan Cercek, MD, FACC, FAHA, Charles E. Chambers, MD, FACC, FSCAI, Stephen G. Ellis,* MD, FACC, Robert A. Guyton, MD, FACC, Steven M. Hollenberg,* MD, FACC, Umesh ...

Several ribozyme constructs have been used to dissect aspects of the group I self-splicing reaction. The Tetrahymena L-21 ScaI ribozyme, the best studied of these intron analogues, catalyzes a reaction analogous to the first step of self-splicing, in which a 5'-splice site analogue (S) and guanosine (G) are converted into a 5'-exon analogue (P) and GA. This ribozyme preserves the active site bu...

The Appropriate Use Criteria for Coronary Revascularization (AUC) were created in 2009 [1,2] and updated in 2012 [3] through a rigorous process and then endorsed by major cardiovascular societies. The AUC were developed from a limited set of carefully defined clinical scenarios; they were not envisioned as covering every clinical situation, but rather, descriptive of common ones. The AUC have b...