نتایج جستجو برای: ژن brca1
تعداد نتایج: 23914 فیلتر نتایج به سال:
سرطان پستان شایع ترین سرطان و دومین عامل منجر به مرگ ناشی از سرطان در بین زنان می باشد. اگرچه مکانیسم (های) دخیل در بروز سرطان پستان هنوز تا حدود زیادی ناشناخته باقی مانده اند، اما مشخص شده است که پیشرفت و گسترش سرطان پستان درگیر با انواع مختلفی از ژن ها از جمله brca1 است. یکی از بزرگترین مشکلاتی که بر سر راه شیمی درمانی سرطان قرار دارد عدم وجود داروهای فعال و موثر و همچنین ایجاد مقاومت دارویی...
2. THE BREAST CANCER SUSCEPTIBILITY GENE 1 (BRCA1) ………………………….. 10 2.1 The BRCA1 gene is large with two distinct promoters 2.2 The BRCA1 protein is nuclear and has several functional domains 2.3 BRCA1 expression 2.4 Pathological variants of the BRCA1 gene 2.4.1 There is a wide spectrum of BRCA1 germline mutations 2.4.2 Germline mutations are found at a high frequency in families with multiple a...
Evidence is accumulating to suggest that some of the diverse functions associated with BRCA1 may relate to its ability to transcriptionally regulate key downstream target genes. Here, we identify S100A7 (psoriasin), S100A8, and S100A9, members of the S100A family of calcium-binding proteins, as novel BRCA1-repressed targets. We show that functional BRCA1 is required for repression of these fami...
The breast cancer susceptibility gene 1 (BRCA1) inactivation in sporadic epithelial ovarian carcinoma (EOC) is common and low BRCA1 expression is associated with promoter hypermethylation. The clinical validation of BRCA1 methylation as a prognostic marker in EOC remains unresolved. The aim of the present study was to determine the aberrant promoter methylation of BRCA1 in benign and malignant ...
BACKGROUND We have previously reported an array comparative genomic hybridization profile that identifies triple-negative breast cancers (TNBC), with BRCA1 dysfunction and a high sensitivity to intensified dose bifunctional alkylating agents. To determine the effect of conventional-dose chemotherapy in patients with this so-called BRCA1-like profile, clinical characteristics and survival were s...
BRCA1 expression is repressed by aberrant cytosine methylation in sporadic breast cancer. We hypothesized that aberrant cytosine methylation of the BRCA1 promoter was associated with the transcriptionally repressive effects of histone hypoacetylation and chromatin condensation. To address this question, we developed an in vitro model of study using normal cells and sporadic breast cancer cells ...
The Potential Contribution of BRCA Mutations to Early Onset and Familial Breast Cancer in Uzbekistan
Introuduction Breast cancer is the most common malignancy in women and affects approximately 1 out of 8 females in the US. Risk of developing breast cancer is strongly influenced by genetic factors. Germ-line mutations in BRCA1 and BRCA2 genes are associated with 5-10% of breast cancer incidence. To reduce the risk of developing cancer and to increase the likelihood of early detection, carriers...
BRCA1 has been implicated in numerous DNA repair pathways that maintain genome integrity, however the function responsible for its tumor suppressor activity in breast cancer remains obscure. To identify the most highly conserved of the many BRCA1 functions, we screened the evolutionarily distant eukaryote Saccharomyces cerevisiae for mutants that suppressed the G1 checkpoint arrest and lethalit...
The breast cancer susceptibility gene BRCA1 encodes a nuclear protein, which functions as a tumor suppressor and is involved in gene transcription and DNA repair processes. Many families with inherited breast and ovarian cancers have mutations in the BRCA1 gene. However, only a few studies have reported on the mechanism underlying the regulation of BRCA1 expression in humans. In this study, we ...
Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular mechanism and the impact in BRCA1-associated tumorigenesis remain unclear. Here, we show that BRCA1 regulates Nrf2-dependent antioxidant signaling by physically interacting with Nrf2 and promoting its stability and activ...
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