background: it is reasonable to think that some biochemical characteristics of follicular fluid (ff) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and embryo development. objective: this study was carried out to evaluate the levels of ff homocysteine (hcy) in ivf candidate polycystic ovary syndro...

background: the uterus is a dynamic tissue responding to hormonal changes during reproductive cycles. as such, uterine stem cells have been studied in recent years. transcription factors oct4 and sox2 are critical for effective maintenance of pluripotent cell identity. objective: the present research evaluated the mrna expression of oct4 and sox2 in the uterine tissues of ovariectomized mice tr...

Two novel dicationic binuclear Cu(I) complexes of the type [{(BPPP)E2)}Cu]2[BF4]2 (E = S (3a); Se (3b)) bearing (BPPP)E2 (BPPP bis(diphenyl phosphino)pyridine) pincer systems were isolated, and structurally characterized. The...

We characterized the NADPH-dependent metabolism of 17beta-estradiol (E2) by liver microsomes from 21 male and 12 female human subjects. A large number of radioactive estrogen metabolite peaks were detected following incubations of [3H]E2 with male or female human liver microsomes in the presence of NADPH. The structures of 18 hydroxylated or keto estrogen metabolites formed by these microsomes ...

Background: Electric-quadrupole ($E2$) strengths relate to the underlying quadrupole deformation of a nucleus and present challenge for many nuclear theories. Mirror nuclei in vicinity line $N=Z$ represent convenient laboratory testing deficiencies such models, making use isospin-symmetry systems. Purpose: Uncertainties associated with literature $E2$ \textsuperscript{23}Mg are some largest $T_...

The estrus cycle affects the circadian body temperature (Tb) and activity rhythms, and progesterone is related to these alterations. However, it is not clear whether estrogen (E2) influences it. The present study examined whether E2 affects the circadian Tb and activity rhythm. Ovariectomized rats were implanted with a silastic plate with or without E2 underneath the dorsal skin (E2(-) and E2(+...

The hormone estrogen (E2) binds the estrogen receptor to promote transcription of E2-responsive genes in the breast and other tissues. E2 also has links to genomic instability, and elevated E2 levels are tied to breast cancer. Here, we show that E2 stimulation causes a rapid, global increase in the formation of R-loops, co-transcriptional RNA-DNA products, which in some instances have been link...

Immunological research of steroid-depended chemical carcinogenesis in humans is based on positive experience the clinical usage selective estrogen receptor modulators and experimental design immunological methods for human protection from environmental carcinogens. Our study aimed idiotypic antibodies against benzo[a]pyrene, estradiol progesterone (IgA1-Bp, IgA1-E2 IgA1-Pg), connection with ant...