The clinical efficacy of anti-angiogenic therapies has been difficult to predict, and biomarkers that can predict responsiveness are sorely needed in this era of personalized medicine. CVX-060 is an angiopoietin-2 (Ang2) targeting therapeutic, consisting of two peptides that bind Ang2 with high affinity and specificity, covalently fused to a scaffold antibody. In order to optimize the use of th...

A method is explored to remove tall building shadows in true color and color infrared urban aerial images based on the theory of color constancy. This paper first uses the specthem ratio and Otsu threshold segmentation methods to detect building shadows on urban aerial true color and color infrared aerial images. Then, based on the shadow detection result, one of the color constancy algorithms ...

the objective of this study was to investigate the effects of saffron as a natural sunscreen and moisturizer. the pollens of the saffron were dried and powdered in a grinder. the experimental formulations included a homosalate (8%) lotion reference, lotions with 2, 4 and 8% of grinded saffron, and the control lotion base without saffron. the lotions containing saffron were prepared like homosal...

We investigated the mode of the 5-HT3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives, YM060, YM114 (KAE-393), YM-26103-2 and YM-26308-2, against 5-HT-induced transient bradycardia in anesthetized rats. Results were compared with those of ondansetron and granisetron. YM060 (0.03-0.1 microgram/kg, i.v.), YM114 (0.03-0.3 microgram/kg, i.v.), YM-26103-2 (0.01-0.03 microgram/kg, ...

Hydraulic jumps formed in closed rectangular sloping conduits aree investigated experimentally. Both positive and negative slopes are considered. The results are analyzed in terms of the inlet Froude number, the bottom slope and the inflow depth ratio. The experiments are conducted in a laboratory flume. Nineteen models are tested. Ten model for positive slope and another ten models nine negati...

This paper investigates the antecedents of member retention for virtual communities. This research theorizes the motivating mechanism from both perspectives of the information seekers and providers. Four antecedents communication breadth, depth, responsiveness, and cross-posting have a statistically significant influence on member retention. Furthermore, we have found that communication breadth...

Despite tremendous popularity of video games, there have been concerns about their detrimental effects on children. The game rating systems were developed to assist parents in monitoring their children’s gaming experiences. This paper explores how parents in Iran, as a society without established media rating systems, control their children’s gaming experiences. Mixed methods of semi-structured...