It has been shown previously that sigma receptor agonists reveal potential antidepressant activity in experimental models. Moreover, some data indicate sigma receptor contribution to stress-induced responses (e.g., conditioned fear stress in mice), though the mechanism by which sigma ligands can exert their effects, remains unclear. Recent studies have indicated that antidepressant drugs (ADs) ...

Public awareness is crucial in the prevention and management of pandemic outbreaks. Accordingly, this study aimed to develop a scale that measures individuals’ on The investigated psychometric properties Pandemic Awareness Scale (PAS) Turkish sample (n = 1303) during COVID-19 pandemic. exploratory-factor-analysis (EFA) results 903) indicated high internal consistency reliability (α .89) suggest...

α4-Laminins, such as laminins 411 and 421, are mesenchymal laminins expressed by vascular and lymphatic endothelial cells, leukocytes and other normal cell types. These laminins are recognized by α6β1 and α6β4 integrins and MCAM (CD146), and promote adhesion and migration of the cells. α4-Laminins are also expressed and secreted by some tumor cells and strongly promote tumor cell migration. Mor...

1. Current antitussive medications have limited efficacy and often contain the opiate-like agent dextromethorphan (DEX). The mechanism whereby DEX inhibits cough is ill defined. DEX displays affinity at both NMDA and sigma receptors, suggesting that the antitussive activity may involve central or peripheral activity at either of these receptors. This study examined and compared the antitussive ...

El propósito de este estudio es establecer el perfil neuropsicológico no lingüístico las variantes la Afasia Progresiva Primaria, mediante una revisión sistemática literatura los últimos 5 años. La búsqueda y manual avanzada se llevó a cabo en bases datos Scopus, PubMed, Web of Science Google Académico para identificar estudios que describieran Primaria (APP), establecieron criterios inclusión ...