DQ-113 is a new quinolone with potent activity against gram-positive pathogens. The in vivo activity of DQ-113 against Streptococcus pneumoniae was compared with those of gatifloxacin and ciprofloxacin in a mouse model. For this purpose, two strains of S. pneumoniae were used: penicillin-susceptible S. pneumoniae (PSSP) and penicillin-resistant S. pneumoniae (PRSP). The survival rates of mice i...

Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate epithelium and is highly up-regulated in prostate cancer. We previously reported a series of novel small molecule inhibitors targeting PSMA. Two compounds, MIP-1072, (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid, and MIP-1095, (S)-2-(3-((S)-1carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ure...

In this paper, we investigate the bulk service queue with Bernoulli vacation schedule and restricted admissibility introduced and studied by Madan and Abu-Dayyeh, [Revista Investigacion Operacional, Vol.24, No.2, pp.113-123, 2003]. Madan and Abu-Dayyeh assume exponentially distributed service times while we allow these times to be generally distributed. We obtain various performance measures th...

Human cytomegalovirus (HCMV) infection of a cell containing latent Kaposi's sarcoma-associated herpesvirus (KSHV) results in the activation of KSHV lytic replication and the production of infectious virus. In this study, we examined the HCMV genes identified as having a role in the activation of HCMV early genes for their ability to activate KSHV lytic replication. It was found that the UL112-1...

Abstract Huang and Wong (Acta Inform 21(1):113–123, 1984) proposed a polynomial-time dynamic-programming algorithm for computing optimal generalized binary split trees. We show that their is incorrect. Thus, it remains open whether such trees can be computed in polynomial time. Spuler (Optimal search using two-way key comparisons, PhD thesis, 1994) modifying Wong’s to obtain an different proble...

113–123] proved that the convergence rate of the preconditioned Gauss–Seidel method for irreducibly diagonally dominant Z-matrices with a preconditioner I + S α is superior to that of the basic iterative method. In this paper, we present a new preconditioner I + K β which is different from the preconditioner given by Kohno et al. and prove the convergence theory about two preconditioned iterati...

Stimulus-selectivity in phenomena such as the McCollough effect and other contingent after effects are controversial. Word specific McCollough effects have been reported (Allan et al., Percept Psychophys 1989;45:104-113) that suggest an associative model rather then a neural one. However, failures to replicate make this finding controversial (Humphrey et al., J Exp Psychol: Gen 123:86-90). We a...