Patients with systemic reactions (SR) to Hymenoptera stings are successfully treated by venom immunotherapy (VIT), but there is not yet a general agreement on the criteria for stopping VIT. We discuss the importance of the venom-specific IgE levels among these criteria. In particular, the results from a recent study evaluating the IgE changes during a 5-year VIT, in patients stung and protected...

Serum IgE levels and the expression of low affinity receptor for IgE (Fc epsilon RII/CD23) are increased in cutaneous leishmaniasis. The ligation of CD23 receptor by IgE-anti-IgE immune complexes results in nitric oxide (NO) production, which is a critical leishmanicidal factor. Human monocytes/macrophages express Fc epsilon RII/CD23 after activation with IFN-gamma and IL-4. In the present stud...

background & aim: according to presence of immune system factors in chronic periapical lesions, hypersensitivity reactions may have some role in pathogenesis of these lesions. up to now, among the factors participating in type i hypersensitivity reaction, only one of them has been studied. so the aim of this study was to evaluate the relationship between the presence of ige & number of mast cel...

Amongst people with Cystic Fibrosis, Aspergillus fumigatus is the most frequently cultured fungal pathogen in sputum samples. Elexacaftor/tezacaftor/ivacaftor (ETI) a CFTR modulator which results significant improvements lung function. We investigated effect of ETI therapy on serological response to adult CF patients prescribed ETI. Data from 275 at least one Phe508del mutation were included.. ...

BACKGROUND Venom immunotherapy (VIT) is an effective treatment for subjects with systemic allergic reactions (SR) to Hymenoptera stings, however there are few studies concerning the relevance of the venom specific IgE changes to decide about VIT cessation. We assessed IgE changes during a 5-year VIT, in patients stung and protected within the first 3 years (SP 0-3) or in the last 2 years (SP 3-...