compounds, such as fibrates (hypolipidemic drugs), phthalate ester plasticizers, fatty acid analogues, cause induction of several proteins related to lipid metabolism, including peroxisomal b-oxidation (Px-ox), accompanied by a hypolipidemic effect in rodents. Since the peroxisome proliferatoractivated receptors (PPARs), which are nuclear transcriptional receptors, were found, they have been re...

A chronic reduction in uterine perfusion pressure in pregnant rats is associated with a significant elevation in mean arterial pressure (MAP) and reduction in kidney function. The purpose of this study was to examine the role of endothelin in mediating the hypertension in response to chronic reductions in uterine perfusion pressure in conscious, chronically instrumented, pregnant rats. MAP in p...

The purpose of this study was to determine the role of endothelin in mediating the renal hemodynamic and arterial pressure changes observed during chronic ANG II-induced hypertension. ANG II (50 ng x kg(-1) x min(-1)) was chronically infused into the jugular vein by miniosmotic pump for 2 wk in male Sprague-Dawley rats with and without endothelin type A (ET(A))-receptor antagonist ABT-627 (5 mg...

background because of difficulty in obtaining a 24-hour urine collection in children, a random sample of urine is often used to calculate the urinary calcium to creatinine ratio. urinary calcium excretion might be influenced by genetic, geographic area, etc. in this study, the value of urinary calcium, creatinine, sodium and potassium excretion and age–related reference values for urine calcium...