Mutation of SLC26A4 is the most common cause of prelingual hearing loss in East Asia. Patients with SLC26A4 mutations have variable phenotypes ranging from non-syndromic hearing loss to Pendred syndrome. Here, we analyzed the correlation between genotype and various inner ear phenotypes and found a possible underlying mechanism. This study included 111 patients with bi-allelic SLC26A4 mutations...

This paper addresses the issue of what potential merits ISO 14001 environmental management systems (EMS) may have to business operations and public policy. It evaluates the EMS structure and applies it to a study that examines approximately eighteen U.S. facilities and government facilities that are designing and implementing ISO 14001-based EMSs. Facilities’ specific EMS components are assesse...

I. History and Discovery 904 A. Calcitonin gene-related peptide: a novel neuropeptide 904 B. Adrenomedullin: a tissue-derived peptide 905 C. Amylin: a pancreatic peptide 905 II. Structure 905 III. Distribution and Regulation of Genes and Peptides 906 A. CGRP: a wide distribution 906 B. AM: upregulation in disease 907 C. Amylin: relevance to diabetes 908 IV. Receptors 908 A. Cloning of CGRP rece...

I. History and Discovery 904 A. Calcitonin gene-related peptide: a novel neuropeptide 904 B. Adrenomedullin: a tissue-derived peptide 905 C. Amylin: a pancreatic peptide 905 II. Structure 905 III. Distribution and Regulation of Genes and Peptides 906 A. CGRP: a wide distribution 906 B. AM: upregulation in disease 907 C. Amylin: relevance to diabetes 908 IV. Receptors 908 A. Cloning of CGRP rece...

Aminoacyl-tRNA synthetases should ensure high accuracy in tRNA aminoacylation. However, the absence of significant structural differences between amino acids always poses a direct challenge for some aminoacyl-tRNA synthetases, such as leucyl-tRNA synthetase (LeuRS), which require editing function to remove mis-activated amino acids. In the cytoplasm of the human pathogen Candida albicans, the C...

0747-5632/$ see front matter 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.chb.2013.02.020 ⇑ Corresponding author. Address: 492 Timberlea Drive Apartment 101, Rochester Hills, MI 48309, United States. Tel.: +1 919 88

View the peer-reviewed version (peerj.com/articles/919), which is the preferred citable publication unless you specifically need to cite this preprint.specific alternative splicing in Arabidopsis thaliana via semi-quantitative PCR.