The evaluation of the outcome of health services technologies is a requirement for their efficient provision in clinical practice. The most reliable evidence for treatment efficacy comes from randomized trials. Randomized trials in general practice pose particular methodological and practical difficulties. In this paper, we discuss how best to plan and manage a clinical trial in this setting. W...

Intensive management of grass seed fields in the poorly drained soils of the Willamette Valley, Oregon, has prompted concern in the capacity of these landscapes and their associated minimally managed riparian areas to process and retain fertilizer N. Our goal was to determine the extent of N losses and effectiveness of a riparian area and an adjacent perennial ryegrass seed field to retain N. T...

Proteinuria is an important cause of tubulointerstitial damage. Antiproteinuric interventions are not always successful, and residual proteinuria often leads to renal failure. This indicates the need for additional treatment modalities by targeting the harmful downstream consequences of proteinuria. We previously showed that proteinuria triggers renal lymphangiogenesis before the onset of inter...

MICHAEL J. LENOX Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-8025 Fax: (919) 681-6244 mlenox@duke.edu SCOTT F. ROCKART Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7998 Fax: (919) 681-6244 srockart@duke.edu ARIE Y. LEWIN Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7832 Fa...

MICHAEL J. LENOX Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-8025 Fax: (919) 681-6244 mlenox@duke.edu SCOTT F. ROCKART Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7998 Fax: (919) 681-6244 srockart@duke.edu ARIE Y. LEWIN Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7832 Fa...

MICHAEL J. LENOX Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-8025 Fax: (919) 681-6244 mlenox@duke.edu SCOTT F. ROCKART Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7998 Fax: (919) 681-6244 srockart@duke.edu ARIE Y. LEWIN Fuqua School of Business Duke University PO Box 90210 Durham, NC 27708 Tel: (919) 660-7832 Fa...

Address correspondence to: Dr. Victor J. Dzau Mandel Center for Hypertension Research Division of Cardiovascular Medicine Department of Medicine Duke University Medical Center, Box 3701 GSRBII, 210 Research Drive Durham, NC 27710 Tel: 919-684-2255 Fax: 919-684-4801 victor.dzau@duke.edu Dr. Sophie Dal-Pra Mandel Center for Hypertension Research Division of Cardiovascular Medicine Department of M...

The alpha4 laminin subunit is a component of the basement membrane of blood vessels where it codistributes with the integrins alphavbeta3, alpha3beta1, and alpha6beta1. An antibody against the G domain (residues 919-1207; G(919-1207)) of the alpha4 laminin subunit inhibits angiogenesis in a mouse-human chimeric model, indicating the functional importance of this domain. Additional support for t...

1E-mail: yuanhui.zhang@gmail.com . Telephone: (919) 271-6331. 2E-mail: haipengwu1989@gmail.com . Telephone: (734) 834-3016 3Member, Institute of Industrial Engineers. E-mail: btdenton@umich.edu . Telephone: (734) 763-2060. Fax: (734) 7643451. 4Fellow, Institute of Industrial Engineers, and corresponding author. E-mail: jwilson@ncsu.edu . Telephone: (919) 5156415. Fax: (919) 515-5281. 5Member, I...