background: a powerful and improved technique, proton induced x-ray emission (pixe) has been performed-yielding the elemental composition of 17 samples of surgically excised malignant and normal tumors of breast tissue. the samples without any further process as thick targets were put on capton foil backing. there are no homogenizing processes. the pixe spectra analysis was performed using he n...

While a range of miRNAs have been shown to be dysregulated in the circulation of patients with breast cancer, little is known about the relationship between circulating levels and tumour characteristics. The aim of this study was to analyse alterations in circulating miRNA expression during tumour progression in a murine model of breast cancer, and to detemine the clinical relevance of identifi...

INTRODUCTION Ferromagnetic port-containing breast tissue expanders are currently labeled MRI-unsafe because of the presumption that magnets should not enter the machine. However, designating these devices as MRI-unsafe can lead to unnecessary procedures or suboptimal imaging choices. This study provides an ex vivo analysis of how breast tissue expanders behave when subjected to strong magnetic ...

CONCLUSION: Our results indicate that there may be a benefit to filling tissue expanders with saline or, to a lesser extent, air prior to undergoing MRI. Furthermore, less than 1 kg is required to prevent rotation of the tissue expander, indicating that prone positioning may be useful in preventing palpable movement of the device. Thus, MRI can reasonably be considered in patients with breast t...

The purpose of this study was to evaluate the feasibility of assessing bladder and rectal point doses, using orthogonal radiographs without treatment planning, for vaginal cylinder applicator (VC), high-dose-rate (HDR) vaginal cuff brachytherapy (BT) after hysterectomy. Thirty-three VC HDR BT treatment plans from 31 postop- erative endometrial cancer patients were retrospectively analyzed. Sing...

INTRODUCTION Osteoradionecrosis (ORN) of the chest wall is a rare complication after whole-breast radiotherapy (RT). Herein, we report a case of ORN involving the underlying ribs following adjuvant whole-breast RT using standard fractionation and conduct a review of the literature. CASE REPORT A previously well 43-year-old female with right-sided, early-stage, node-negative breast cancer was ...

Introduction: N-nitroso-N-methylurea (NMU) is a carcinogen from nitrosamines family, which has been used to induce breast cancer in rodents. This model of breast cancer is very similar to the estrogen dependent breast cancer in human. As a continuation of our recent works, in the present study, the expressions of both p53 and p27 were investigated in NMU-induced breast cancer in Wistar Albin...

The detection and quantification of apoptotic cells is a key process in cancer research, particularly during the screening anticancer therapeutics mechanistic studies using preclinical models. Intravital optical imaging enables high-resolution visualisation cellular events live organisms; however, there are few fluorescent probes that can reliably provide functional readouts situ without interf...

Introduction: Of the factors leading to false negative results in mammography is breast tissue density, and by increasing the density of breast tissue in mammography, the mammography sensitivity decreases. On the other hand, increasing the breast tissue density leads to increased risk of breast cancer. Various factors such as inheritance, genetics, hormonal and reproductive factors, and nutriti...

introduction: delivering maximum dose to tumor and minimum dose to normal tissues is the most important goal in radiotherapy. according to icru, the maximum acceptable uncertainty in the delivered dose compared to the prescribed dose should be lower than 5%, and this is because of the relationship between absorbed dose, tumor control and normal tissue damage. absorbed dose accuracy is investiga...