background: the unplanned departure of endotracheal tube is one of the main complications for endotracheal intubation. in addition to endotracheal extubation, its movement can also lead to damage to the oral cavity. stabilizing endotracheal tube is the most important factor that can prevent unplanned departure of endotracheal tube as well as its movement. the current study was done with the aim...

micrornas participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of micrornas in the pathogenesis of asthma. a review of the english medical literatures was conducted by searching pubmed for studies concerning asthma and micrornas. the results of the present study indicate that micrornas play important roles in regulating asthma immune res...

conclusions although some studies showed association between anemia and extubation failure, the current study could not confirm it. the study showed that males, regardless of the hct level, had a better extubation success rate than those of females. results there was no significant association between the level of hct concentration and extubation failure (8.9% vs. 9.2%, p = 0.507). gender and a...

PURPOSE Sedatives must be carefully titrated for patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) as oversedation may lead to disastrous respiratory outcomes. This study aimed to investigate the relations between the effect-site concentration (Ce) of propofol and sedation and airway obstruction levels in patients with OSAHS. MATERIALS AND METHODS In 25 patients with OSAHS, seda...

Interleukin (IL)-22 is an effector cytokine, which acts primarily on epithelial cells in the skin, gut, liver and lung. Both pro- and anti-inflammatory properties have been reported for IL-22 depending on the tissue and disease model. In a murine model of allergic airway inflammation, we found that IL-22 is predominantly produced by innate lymphoid cells in the inflamed lungs, rather than TH ce...

Vascular endothelial growth factor (VEGF) is a mediator of airway inflammation and remodelling in asthma. Transforming growth factor (TGF)-beta(1) plays pivotal roles in diverse biological processes, including tissue remodelling and repair in a number of chronic lung diseases. However, there are few studies elucidating the interactions between VEGF and TGF-beta(1) in allergic airway disease. A ...

BACKGROUND/AIMS Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against c-kit and the platelet-derived growth factor receptor. We compared the effects of fluticasone and nilotinib on airway remodeling in a chronic asthma model...

Cystic fibrosis (CF) is an inherited disease that primarily affects the lungs and the digestive system, however, it also affects a number of other organs and systems. More than 90% of mortality of  CF patients is due to lung complications.  Healthy lungs are important for a long life for people with CF, We will discuss two important topics for maintaining respiratory health. Chronic use of drug...

TO THE EDITOR: In view of the Viewpoint by Solbert Permutt (3) in this issue of the Journal of Applied Physiology, it is becoming clear that the extent of decline in pulmonary function in asthmatics is not a simple function of the degree of smooth muscle shortening, but is the manifestation of complicated relationships among baseline airway structure, the degree of airway smooth muscle shorteni...